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IPR037685 is a RNA polymerase RBP11.
<p>The eukaryotic RPB11 subunit of RNA polymerase (RNAP) II is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells [[cite:PUB00079994]]. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III. RNAP II is responsible for the synthesis of mRNA precursor [[cite:PUB00008731]]. The RPB11 subunit heterodimerizes with the RPB3 subunit, and together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, and stabilizes their association [[cite:PUB00087474], [cite:PUB00087475]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA polymerase II activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. | ||
| Cellular component | RNA polymerase II, core complex | RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. | ||
| Biological process | Transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | DNA-directed RNA polymerase; TAIR: AT3G52090.1 DNA-directed RNA polymerase, RBP11-like protein; Swiss-Prot: sp|Q38859|NRPBB_ARATH DNA-directed RNA polymerases II, IV and V subunit 11; TrEMBL-Plants: tr|I3T213|I3T213_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0550300 | 12 | ||
| – | DNA-directed RNA polymerase; TAIR: AT3G52090.1 DNA-directed RNA polymerase, RBP11-like protein; Swiss-Prot: sp|Q38859|NRPBB_ARATH DNA-directed RNA polymerases II, IV and V subunit 11; TrEMBL-Plants: tr|I3T213|I3T213_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0550300 | 12 | ||
| – | DNA-directed RNA polymerase; TAIR: AT3G52090.1 DNA-directed RNA polymerase, RBP11-like protein; Swiss-Prot: sp|Q38859|NRPBB_ARATH DNA-directed RNA polymerases II, IV and V subunit 11; TrEMBL-Plants: tr|I3T213|I3T213_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0550300 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06926 | CDD | 1 | 33.33 |