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IPR037875 is a Ribosome biogenesis protein Bms1, N-terminal.
<p>Bms1 is an essential, evolutionarily conserved, nucleolar protein. Its depletion interferes with processing of the 35S pre-rRNA at sites A0, A1, and A2, and the formation of 40S subunits. Bms1, the putative endonuclease Rc11, and the essential U3 small nucleolar RNA form a stable subcomplex that is believed to control an early step in the formation of the 40S subunit [[cite:PUB00087771]]. The N terminus of Bms1 contains a guanine nucleotide-binding (G) domain that functions intramolecularly. It is believed that Rc11 activates Bms1 by acting as a guanine-nucleotide exchange factor (GEF) to promote GDP/GTP exchange, and that activated (GTP-bound) Bms1 delivers Rc11 to the preribosomes [[cite:PUB00072547]].</p> <p>This entry represents the N-terminal domain of Bms1.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | GTP binding | Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Ribosome biogenesis protein BMS1; TAIR: AT1G06720.2 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|O94653|BMS1_SCHPO Ribosome biogenesis protein bms1; TrEMBL-Plants: tr|I1LQB2|I1LQB2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0756800 | 18 | ||
| – | Ribosome biogenesis protein BMS1; TAIR: AT1G06720.2 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|O94653|BMS1_SCHPO Ribosome biogenesis protein bms1; TrEMBL-Plants: tr|I1LQB2|I1LQB2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0756800 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |