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IPR039761 is a Ribosome biogenesis protein Bms1/Tsr1.
<p>Bms1p and Tsr1p represent a new family of factors required for ribosome biogenesis. They are each independently required for 40S ribosomal subunit biogenesis. Bms1p, a protein required for pre-rRNA processing, contains an evolutionarily conserved guanine nucleotide-binding (G) domain with five conserved polypeptide loops designated G1 through G5, which form contact sites with the guanine nucleotide or coordinate the Mg(2+) ion. Sequences resembling G1 (consensus [GA]-x(4)-G-K-[ST]; also known as a P-loop), G4 (consensus [NT]-K-x-D), and G5 (consensus S-[AG] are present in all Bms1 proteins, and either fully conform with the consensus or contain, at most, single conservative substitutions. The G2 motif (consensus G-P-[IV]-T) contains a T residue involved in the coordination of the Mg(2+) required for GTP hydrolysis. The G3 motif diverges from the consensus found in G proteins, D-x(2)-G; however, the D residue is replaced with the conserved E residue. In contrast, Tsr1p lacks a P-loop and is not predicted to bind GTP. It functions at a later step of 40S ribosome production, possibly in assembly and/or export of 43S pre-ribosomal subunits to the cytosol [[cite:PUB00013952], [cite:PUB00072547], [cite:PUB00072548]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Ribosome biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Pre-rRNA-processing protein TSR1 like; TAIR: AT1G42440.1 pre-rRNA-processing TSR1-like protein; Swiss-Prot: sp|Q5XGY1|TSR1_XENLA Pre-rRNA-processing protein TSR1 homolog; TrEMBL-Plants: tr|I1JSW0|I1JSW0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0435400 | 12 | ||
| – | Pre-rRNA-processing protein TSR1 like; TAIR: AT1G42440.1 pre-rRNA-processing TSR1-like protein; Swiss-Prot: sp|Q5XGY1|TSR1_XENLA Pre-rRNA-processing protein TSR1 homolog; TrEMBL-Plants: tr|I1JSW0|I1JSW0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0435400 | 12 | ||
| – | Ribosome biogenesis protein BMS1; TAIR: AT1G06720.2 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|O94653|BMS1_SCHPO Ribosome biogenesis protein bms1; TrEMBL-Plants: tr|I1LQB2|I1LQB2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0756800 | 18 | ||
| – | Ribosome biogenesis protein BMS1; TAIR: AT1G06720.2 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|O94653|BMS1_SCHPO Ribosome biogenesis protein bms1; TrEMBL-Plants: tr|I1LQB2|I1LQB2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0756800 | 18 | ||
| – | Ribosome biogenesis protein BMS1; TAIR: AT1G06720.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q14692|BMS1_HUMAN Ribosome biogenesis protein BMS1 homolog; TrEMBL-Plants: tr|I1LQB2|I1LQB2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0756800 | 8 | ||
| – | Ribosome biogenesis protein BMS1; TAIR: AT1G06720.2 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q14692|BMS1_HUMAN Ribosome biogenesis protein BMS1 homolog; TrEMBL-Plants: tr|I1LQB2|I1LQB2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0501300 | 8 | ||
| – | Ribosome biogenesis protein BMS1; TAIR: AT1G06720.2 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q14692|BMS1_HUMAN Ribosome biogenesis protein BMS1 homolog; TrEMBL-Plants: tr|I1LQB2|I1LQB2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0501300 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 14.29 |