Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR039226 is a Ski3/TTC37.
<p>This entry includes superkiller protein 3 (Ski3) from yeasts and plants and tetratricopeptide repeat protein 37 (TTC37/SKI3) from animals. They are a component of the Ski complex required for exosome-mediated RNA surveillance [[cite:PUB00089519], [cite:PUB00151108], [cite:PUB00151109]].</p> <p>In budding yeasts, the SKI complex (Ski2-Ski3-Ski8) is a helicase complex functioning with the RNA-degrading exosome to mediate the 3'-5' messenger RNA (mRNA) decay in turnover and quality-control pathways [[cite:PUB00089519]]. Ski3 has also been shown to repress dsRNA virus propagation by specifically blocking translation of viral mRNAs [[cite:PUB00089326]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | RNA catabolic process | The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. | ||
| Cellular component | Ski complex | A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Tetratricopeptide repeat-containing protein; TAIR: AT1G76630.2 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp|F4I3Z5|SKI3_ARATH Tetratricopeptide repeat protein SKI3; TrEMBL-Plants: tr|K7K5N8|K7K5N8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0462200 | 13 | ||
| – | Tetratricopeptide repeat-containing protein; TAIR: AT1G76630.2 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp|F4I3Z5|SKI3_ARATH Tetratricopeptide repeat protein SKI3; TrEMBL-Plants: tr|K7K5N9|K7K5N9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0462200 | 14 | ||
| – | Tetratricopeptide repeat-containing protein; TAIR: AT1G76630.2 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp|F4I3Z5|SKI3_ARATH Tetratricopeptide repeat protein SKI3; TrEMBL-Plants: tr|K7K5N9|K7K5N9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0462200 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF48452 | SUPERFAMILY | 1 | 33.33 |