Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR039383

Source: InterPro

Description

IPR039383 is a FHIT family.

<p>FHIT (fragile histidine) proteins are related to the HIT family members that carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid) [[cite:PUB00005228]]. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the FHIT branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases [[cite:PUB00008005], [cite:PUB00001122], [cite:PUB00008004]]. FHIT plays a very important role in the development of tumours. In fact, FHIT deletions are among the earliest and most frequent genetic alterations in the development of tumours [[cite:PUB00015781], [cite:PUB00089564]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
LotjaGi6g1v0046600.1
– Bis(5'-adenosyl)-triphosphatase; TAIR: AT5G58240.1 FRAGILE HISTIDINE TRIAD; Swiss-Prot: sp|F4KEV7|FHIT_ARATH Bifunctional bis(5'-adenosyl)-triphosphatase/adenylylsulfatase FHIT; TrEMBL-Plants: tr|I3S0X9|I3S0X9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0046600
Domains
14
LotjaGi6g1v0046700.1
– Bis(5-adenosyl)-triphosphatase-like protein; TAIR: AT5G58240.1 FRAGILE HISTIDINE TRIAD; Swiss-Prot: sp|F4KEV7|FHIT_ARATH Bifunctional bis(5'-adenosyl)-triphosphatase/adenylylsulfatase FHIT; TrEMBL-Plants: tr|C6T520|C6T520_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi6g1v0046700
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01275 CDD 1 50.00