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IPR019808 is a Histidine triad, conserved site.
<p>The Histidine Triad (HIT) motif, His-x-His-x-His-x-x (x, a hydrophobic amino acid) was identified as being highly conserved in a variety of organisms [[cite:PUB00001122]]. Crystal structure of rabbit Hint, purified as an adenosine and AMP-binding protein, showed that proteins in the HIT superfamily are conserved as nucleotide-binding proteins and that Hint homologues, which are found in all forms of life, are structurally related to Fhit homologues and GalT-related enzymes, which have more restricted phylogenetic profiles [[cite:PUB00003940]]. Hint homologues including rabbit Hint and yeast Hnt1 hydrolyse adenosine 5' monophosphoramide substrates such as AMP-NH2 and AMP-lysine to AMP plus the amine product and function as positive regulators of Cdk7/Kin28 in vivo [[cite:PUB00008002]]. Fhit homologues are diadenosine polyphosphate hydrolases [[cite:PUB00000430]] and function as tumour suppressors in human and mouse [[cite:PUB00008003]] though the tumour suppressing function of Fhit does not depend on ApppA hydrolysis [[cite:PUB00008004]]. The third branch of the HIT superfamily, which includes GalT homologues, contains a related His-X-His-X-Gln motif and transfers nucleoside monophosphate moieties to phosphorylated second substrates rather than hydrolysing them [[cite:PUB00008005]].</p> <p>The bovine protein kinase C inhibitor, PKCI-1, is an inhibitor protein that binds zinc without the use of zinc-finger motifs [[cite:PUB00002608]]. Each protein molecule binds one zinc ion via a novel binding site containing 3 closely-spaced histidine residues [[cite:PUB00001599]]. This region, referred to as the histidine triad (HIT) [[cite:PUB00001599]], has been identified in various prokaryotic and eukaryotic proteins of uncertain function [[cite:PUB00001122]].</p> <p>The signature pattern used in this entry contains the region of the histidine triad and includes the three conserved histidine residues which are thought to bind the zinc ion.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: bis(5'-adenosyl)-triphosphatase-like [Cucumis sativus] gi|449495038|ref|XP_004159717.1| | 12 | ||
| – | Histidine triad family protein [Arabidopsis lyrata subsp]. lyrata] gi|297792041|ref|XP_002863905.1| | 11 | ||
| – | PREDICTED: transcription factor bHLH140-like [Glycine max] gi|356496191|ref|XP_003516953.1| | 28 | ||
| – | PREDICTED: 14 kDa zinc-binding protein-like [Cicer arietinum] gi|502091782|ref|XP_004489633.1| | 12 | ||
| – | 14 kDa zinc-binding protein [Medicago truncatula] gi|357475225|ref|XP_003607898.1| | 12 | ||
| – | Histidine triad nucleotide-binding protein; TAIR: AT5G48545.1 histidine triad nucleotide-binding 3; Swiss-Prot: sp|F4K1R2|HINT3_ARATH Adenylylsulfatase HINT3; TrEMBL-Plants: tr|A0A072U9P7|A0A072U9P7_MEDTR Histidine triad nucleotide-binding protein; Found in the gene: LotjaGi1g1v0593200 | 17 | ||
| – | Histidine triad nucleotide binding protein; TAIR: AT3G56490.1 HIS triad family protein 3; Swiss-Prot: sp|Q8GUN2|HINT1_ARATH Adenylylsulfatase HINT1; TrEMBL-Plants: tr|I3T4V1|I3T4V1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0654200 | 13 | ||
| – | Histidine triad nucleotide binding protein; TAIR: AT1G31160.1 HISTIDINE TRIAD NUCLEOTIDE-BINDING 2; Swiss-Prot: sp|P42856|ZB14_MAIZE 14 kDa zinc-binding protein; TrEMBL-Plants: tr|Q2MGQ9|Q2MGQ9_MEDTR Histidine triad (HIT) protein; Found in the gene: LotjaGi4g1v0082900 | 13 | ||
| – | Transcription factor bHLH140; TAIR: AT5G01310.1 APRATAXIN-like protein; Swiss-Prot: sp|Q9M041|BH140_ARATH Transcription factor bHLH140; TrEMBL-Plants: tr|K7K399|K7K399_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0162600 | 29 | ||
| – | Bis(5'-adenosyl)-triphosphatase; TAIR: AT5G58240.1 FRAGILE HISTIDINE TRIAD; Swiss-Prot: sp|F4KEV7|FHIT_ARATH Bifunctional bis(5'-adenosyl)-triphosphatase/adenylylsulfatase FHIT; TrEMBL-Plants: tr|I3S0X9|I3S0X9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0046600 | 14 | ||
| – | Bis(5-adenosyl)-triphosphatase-like protein; TAIR: AT5G58240.1 FRAGILE HISTIDINE TRIAD; Swiss-Prot: sp|F4KEV7|FHIT_ARATH Bifunctional bis(5'-adenosyl)-triphosphatase/adenylylsulfatase FHIT; TrEMBL-Plants: tr|C6T520|C6T520_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi6g1v0046700 | 15 | ||
| – | Bis(5'-adenosyl)-triphosphatase; TAIR: AT5G58240.1 FRAGILE HISTIDINE TRIAD; Swiss-Prot: sp|F4KEV7|FHIT_ARATH Bifunctional bis(5'-adenosyl)-triphosphatase/adenylylsulfatase FHIT; TrEMBL-Plants: tr|C6T520|C6T520_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi6g1v0046700 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF54197 | SUPERFAMILY | 1 | 8.33 |