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IPR039622 is a Methyl-CpG-binding domain-containing protein 10/11.
<p>This entry represents a group of methyl-CpG-binding domain-containing proteins from plants, including MBD10/11 from Arabidopsis.</p> <p>Cytosine methylation at symmetrical CpG and CpNpG sequences plays a key role in the epigenetic control of plant growth and development. In animals, the methylation signal is recognized by methyl-CpG-binding domain (MBD) proteins that specifically bind methylated CpG dinucleotides. In Arabidopsis thaliana 12 putative MBD proteins have been identified. However, the presence of an MBD motif does not necessarily point to methyl-CpG-binding activity. The Arabidopsis proteins AtMBD5, AtMBD6 and AtMBD7 have been proven to bind methyl CpG in vitro and to localize to highly methylated chromocentres in vivo, but none of the other Arabidopsis MBD-containing proteins show these properties, and therefore seem to be non-functional MBDs [[cite:PUB00015391], [cite:PUB00088587]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Methyl-CpG-binding domain protein; TAIR: AT1G15340.1 methyl-CPG-binding domain 10; Swiss-Prot: sp|Q9XI36|MBD10_ARATH Methyl-CpG-binding domain-containing protein 10; TrEMBL-Plants: tr|I3SMM8|I3SMM8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0356500 | 9 | ||
| – | Methyl-CpG-binding domain protein; TAIR: AT1G15340.1 methyl-CPG-binding domain 10; Swiss-Prot: sp|Q9XI36|MBD10_ARATH Methyl-CpG-binding domain-containing protein 10; TrEMBL-Plants: tr|I3SMM8|I3SMM8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0356500 | 9 | ||
| – | Methyl-CpG-binding domain protein; TAIR: AT3G15790.1 methyl-CPG-binding domain 11; Swiss-Prot: sp|Q9LW00|MBD11_ARATH Methyl-CpG-binding domain-containing protein 11; TrEMBL-Plants: tr|A0A1J7I076|A0A1J7I076_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0272500 | 11 | ||
| – | Methyl-CpG-binding domain protein; TAIR: AT3G15790.1 methyl-CPG-binding domain 11; Swiss-Prot: sp|Q9LW00|MBD11_ARATH Methyl-CpG-binding domain-containing protein 11; TrEMBL-Plants: tr|A0A1J7I076|A0A1J7I076_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0272500 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |