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IPR039979

Source: InterPro

Description

IPR039979 is a Pre-mRNA-splicing factor 18.

<p>The splicing factor Prp18 is required for the second step of pre-mRNA splicing. PRP18 appears to be primarily associated with the U5 snRNP.</p> <p>The structure of a large fragment of the Saccharomyces cerevisiae Prp18 is known [[cite:PUB00007365]]. This fragment is fully active in yeast splicing<i>in vitro</i>and includes the sequences of Prp18 that have been evolutionarily conserved. The core structure consists of five α-helices that adopt a novel fold. The most highly conserved region of Prp18, a nearly invariant stretch of 19 aa, forms part of a loop between two α-helices and may interact with the U5 small nuclear ribonucleoprotein particles [[cite:PUB00007365]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008380
Biological process RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0497500_LC.1
– Pre-mRNA-splicing factor 18; TAIR: AT1G54590.1 pre-mRNA-splicing factor-like protein; Swiss-Prot: sp|Q2HJ41|PRP18_BOVIN Pre-mRNA-splicing factor 18; TrEMBL-Plants: tr|I1N9I5|I1N9I5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0497500_LC
Domains
7
LotjaGi4g1v0393300.1
– Pre-mRNA-splicing factor 18; TAIR: AT1G03140.1 splicing factor Prp18 family protein; Swiss-Prot: sp|Q99633|PRP18_HUMAN Pre-mRNA-splicing factor 18; TrEMBL-Plants: tr|I1JNV3|I1JNV3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0393300
Domains
15
LotjaGi4g1v0393500.1
– Pre-mRNA-splicing factor 18; TAIR: AT1G03140.1 splicing factor Prp18 family protein; Swiss-Prot: sp|Q8BM39|PRP18_MOUSE Pre-mRNA-splicing factor 18; TrEMBL-Plants: tr|I1JNV3|I1JNV3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0393500
Domains
14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33