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IPR004098 is a Prp18.
<p>The splicing factor Prp18 is required for the second step of pre-mRNA splicing. PRP18 appears to be primarily associated with the U5 snRNP.</p> <p>The structure of a large fragment of the Saccharomyces cerevisiae Prp18 is known [[cite:PUB00007365]]. This fragment is fully active in yeast splicing<i>in vitro</i>and includes the sequences of Prp18 that have been evolutionarily conserved. The core structure consists of five α-helices that adopt a novel fold. The most highly conserved region of Prp18, a nearly invariant stretch of 19 aa, forms part of a loop between two α-helices and may interact with the U5 small nuclear ribonucleoprotein particles [[cite:PUB00007365]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. | ||
| Biological process | RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: pre-mRNA-splicing factor 18-like [Glycine max] gi|356504933|ref|XP_003521247.1| | 6 | ||
| – | Pre-mRNA-splicing factor 18; TAIR: AT1G54590.1 pre-mRNA-splicing factor-like protein; Swiss-Prot: sp|Q2HJ41|PRP18_BOVIN Pre-mRNA-splicing factor 18; TrEMBL-Plants: tr|I1N9I5|I1N9I5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0497500_LC | 7 | ||
| – | Pre-mRNA-splicing factor 18; TAIR: AT1G03140.1 splicing factor Prp18 family protein; Swiss-Prot: sp|Q99633|PRP18_HUMAN Pre-mRNA-splicing factor 18; TrEMBL-Plants: tr|I1JNV3|I1JNV3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0393300 | 15 | ||
| – | Pre-mRNA-splicing factor 18; TAIR: AT1G03140.1 splicing factor Prp18 family protein; Swiss-Prot: sp|Q8BM39|PRP18_MOUSE Pre-mRNA-splicing factor 18; TrEMBL-Plants: tr|I1JNV3|I1JNV3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0393500 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |