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IPR040002 is a U6 snRNA-associated Sm-like protein Lsm3.
<p>This entry represents Sm-like protein Lsm3. It can be found in the nuclear Lsm2-8 complex or in the cytoplasmic Lsm1-7 complex.</p> <p>The Lsm2-8 complex associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6.U5 snRNP, and free U6 snRNP). It binds and stabilizes the 3'-terminal poly(U) tract of U6 snRNA and facilitates the assembly of U4-U6 di-snRNP and U4-U6-U5 tri-snRNP [[cite:PUB00065876], [cite:PUB00063326], [cite:PUB00073458]]. The Lsm1-7 complex associates with deadenylated mRNA and promotes decapping in the 5'-3' mRNA decay pathway [[cite:PUB00065876], [cite:PUB00016606]].</p> <p>The Sm and the Lsm proteins, characterised by the Sm-domain, have RNA-related functions. The Sm heptamer ring associates with four (U1, U2, U4, U5) snRNPs, while Lsm2-8 heptamer is part of the U6 snRNP. Another Lsm heptameric complex, Lsm1-7, which differs from Lsm2-8 by one Lsm protein, functions in mRNA decapping, a crucial step in the mRNA degradation pathway [[cite:PUB00082657]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Small nuclear ribonucleoprotein; TAIR: AT1G76860.1 Small nuclear ribonucleoprotein family protein; Swiss-Prot: sp|Q9C6K5|LSM3B_ARATH Sm-like protein LSM3B; TrEMBL-Plants: tr|A0A0J8FV31|A0A0J8FV31_BETVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0598200 | 11 | ||
| – | Small nuclear ribonucleoprotein; TAIR: AT1G76860.1 Small nuclear ribonucleoprotein family protein; Swiss-Prot: sp|Q9C6K5|LSM3B_ARATH Sm-like protein LSM3B; TrEMBL-Plants: tr|Q5N9F1|Q5N9F1_ORYSJ protein; Found in the gene: LotjaGi2g1v0132800 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01730 | CDD | 1 | 50.00 |