Description

IPR001163 is a Sm domain, eukaryotic/archaea-type.

<p>This domain is found in Lsm (like-Sm) proteins, which have a core structure consisting of an open β-barrel with an SH3-like topology.</p> <p>Lsm (like-Sm) proteins have diverse functions, and are thought to be important modulators of RNA biogenesis and function [[cite:PUB00016606], [cite:PUB00016607]]. The Sm proteins form part of specific small nuclear ribonucleoproteins (snRNPs) that are involved in the processing of pre-mRNAs to mature mRNAs, and are a major component of the eukaryotic spliceosome. Most snRNPs consist of seven Sm proteins (B/B', D1, D2, D3, E, F and G) arranged in a ring on a uridine-rich sequence (Sm site), plus a small nuclear RNA (snRNA) (either U1, U2, U5 or U4/6) [[cite:PUB00016608]]. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker [[cite:PUB00001270]]. Other snRNPs, such as U7 snRNP, can contain different Lsm proteins.</p> <p>Lsm proteins are also found in archaebacteria, which do not have any splicing apparatus, suggesting a more general role for Lsm proteins. Archaeal Lsm proteins have been shown to bind to small RNAs and are probably involved in many cellular processes [[cite:PUB00058144]]. Archaeal Lsm proteins are likely to represent the ancestral Lsm domain [[cite:PUB00016613]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 57

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: