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IPR040812 is a RNA helicase UPF1, 1B domain.
<p>UPF1 (or regulator of nonsense transcripts 1 homologue) is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. Together with UPF2 and UPF3, forms a surveillance complex, in which UPF2 acts as a bridge between UPF1 and UPF3. UPF2 and UPF3 are nonenzymatic components of the complex that stimulate the activity of UPF1 [[cite:PUB00095891]]. UPF1 has a N-terminal cysteine/histidine-rich zinc-binding domain (CH/ZBD), a regulatory 1B domain, followed by a helicase core that belongs to superfamily 1 (SF1).</p> <p>This is 1B domain of UPF1 which has a regulatory role. It suffers conformational changes from an inhibitory state to a transition-state complex that modulate RNA binding [[cite:PUB00095891], [cite:PUB00050141]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Regulator of nonsense transcripts 1-like protein; TAIR: AT5G47010.1 RNA helicase; Swiss-Prot: sp|Q9FJR0|RENT1_ARATH Regulator of nonsense transcripts 1 homolog; TrEMBL-Plants: tr|I1J9N5|I1J9N5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0417100 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |