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IPR018999

Source: InterPro

Description

IPR018999 is a RNA helicase UPF1, Cys/His rich zinc-binding domain.

<p>UPF1 (or regulator of nonsense transcripts 1 homologue) is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. Together with UPF2 and UPF3, forms a surveillance complex, in which UPF2 acts as a bridge between UPF1 and UPF3. UPF2 and UPF3 are nonenzymatic components of the complex that stimulate the activity of UPF1 [[cite:PUB00095891]]. UPF1 has a N-terminal cysteine/histidine-rich zinc-binding domain (CH/ZBD), a regulatory 1B domain, followed by a helicase core that belongs to superfamily 1 (SF1).</p> <p>This is the N-terminal CH/ZBD which contains 3 zinc binding motifs that interacts with UPF2 and it also has a cis-inhibitory effect on the ATPase activity. After binding to UPF2, the CH/ZBD suffers a large conformational change that causes the catalytic helicase domain to bind RNA less extensively and triggering its helicase activity [[cite:PUB00041821], [cite:PUB00090071]]. This domain is an unique combination of three zinc-binding motifs arranged into two tandem modules related to the RING-box and U-box domains of ubiquitin ligases [[cite:PUB00041821]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000184
Biological process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
Subterm of
GO:0003677
Molecular function DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
Subterm of
GO:0004386
Molecular function Helicase activity Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix.
Subterm of
GO:0005524
Molecular function ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Subterm of
GO:0005737
Cellular component Cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Subterm of
GO:0008270
Molecular function Zinc ion binding Interacting selectively and non-covalently with zinc (Zn) ions.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj2g3v1987530.1
– PREDICTED: regulator of nonsense transcripts 1 homolog isoform X2 [Cicer arietinum] gi|502160480|ref|XP_004511759.1|
Domains
14
LotjaGi2g1v0417100.1
– Regulator of nonsense transcripts 1-like protein; TAIR: AT5G47010.1 RNA helicase; Swiss-Prot: sp|Q9FJR0|RENT1_ARATH Regulator of nonsense transcripts 1 homolog; TrEMBL-Plants: tr|I1J9N5|I1J9N5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0417100
Domains
21

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00