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IPR041024 is a Mcm6, C-terminal winged-helix domain.
<p>The minichromosome maintenance (Mcm) complex is the replicative helicase in eukaryotic species, that plays essential roles in the initiation and elongation phases of DNA replication. During late M and early G(1), the Mcm complex is loaded onto chromatin to form prereplicative complex in a Cdt1-dependent manner. This entry represents the C-terminal domain of human Mcm6 which is the Cdt1 binding domain (CBD). The structure of CBD exhibits a typical winged helix fold that is generally involved in protein-nucleic acid interaction. The CBD failed to interact with DNA in experiments [[cite:PUB00091416]]. The CBD-Cdt1 interaction involves the helix-turn-helix motif of CBD [[cite:PUB00091416]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | DNA helicase; TAIR: AT5G44635.1 minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|F4KAB8|MCM6_ARATH DNA replication licensing factor MCM6; TrEMBL-Plants: tr|A0A072TUF1|A0A072TUF1_MEDTR DNA helicase; Found in the gene: LotjaGi6g1v0247200 | 32 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |