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IPR041956 is a ATX1/2, ePHD domain.
<p>This entry represents the ePHD finger of A. thaliana histone-lysine N-methyltransferase arabidopsis trithorax-like proteins ATX1, -2, and similar proteins. The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His.</p> <p>ATX1 and -2 are sister paralogs originating from a segmental chromosomal duplication; they are plant counterparts of the Drosophila melanogaster trithorax (TRX) and mammalian mixed-lineage leukemia (MLL1) proteins [[cite:PUB00092133]]. ATX1 is a methyltransferase that trimethylates histone H3 at lysine 4 (H3K4me3). It also acts as a histone modifier and as a positive effector of gene expression [[cite:PUB00092134]]. ATX1 regulates transcription from diverse classes of genes implicated in biotic and abiotic stress responses. It is involved in dehydration stress signaling in both abscisic acid (ABA)-dependent and ABA-independent pathways [[cite:PUB00092135]]. ATX2 is involved in dimethylating histone H3 at lysine 4 (H3K4me2) [[cite:PUB00092136]]. ATX1 and ATX2 are multi-domain proteins that consist of an N-terminal PWWP domain, FYRN- and FYRC (DAST, domain associated with SET in trithorax) domains, a canonical PHD finger, a non-canonical ePHD finger, and a C-terminal SET domain [[cite:PUB00092132]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Histone-lysine N-methyltransferase; TAIR: AT1G05830.1 trithorax-like protein 2; Swiss-Prot: sp|P0CB22|ATX2_ARATH Histone-lysine N-methyltransferase ATX2; TrEMBL-Plants: tr|A0A151TCT2|A0A151TCT2_CAJCA Histone-lysine N-methyltransferase ATX2; Found in the gene: LotjaGi1g1v0529500 | 44 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT1G05830.1 trithorax-like protein 2; Swiss-Prot: sp|P0CB22|ATX2_ARATH Histone-lysine N-methyltransferase ATX2; TrEMBL-Plants: tr|A0A151TCT2|A0A151TCT2_CAJCA Histone-lysine N-methyltransferase ATX2; Found in the gene: LotjaGi1g1v0529500 | 45 | ||
| – | Histone-lysine N-methyltransferase; TAIR: AT1G05830.1 trithorax-like protein 2; Swiss-Prot: sp|P0CB22|ATX2_ARATH Histone-lysine N-methyltransferase ATX2; TrEMBL-Plants: tr|A0A151TCT2|A0A151TCT2_CAJCA Histone-lysine N-methyltransferase ATX2; Found in the gene: LotjaGi1g1v0529500 | 45 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |