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IPR042238

Source: InterPro

Description

IPR042238 is a DNA excision repair protein Rad28/ERCC8/Ckn1/ATCSA-1.

<p>This entry represents a group of DNA excision repair proteins, including Rad28 from budding yeasts [[cite:PUB00092816]], Ckn1 from fission yeasts, ATCSA-1 from Arabidopsis [[cite:PUB00092817]] and ERCC8 (also known as CSA) from animals [[cite:PUB00092818]]. Ckn1 is involved in transcription-coupled nucleotide excision repair [[cite:PUB00075259]]. Human CSA is part of a E3-ubiquitin ligase (E3-ub ligase) complex and plays an important part in transcription-coupled repair (TCR)[[cite:PUB00101303]]. In Arabidopsis, ATCSA-1 is a critical component for initiating the repair of UV-B-induced DNA lesions [[cite:PUB00092817]].</p> <p>Mutations in the CSA gene cause Cockayne syndrome A (CSA), a rare disorder characterised by cutaneous sensitivity to sunlight, abnormal and slow growth, cachectic dwarfism, progeroid appearance, progressive pigmentary retinopathy and sensorineural deafness [[cite:PUB00092815]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006283
Biological process Transcription-coupled nucleotide-excision repair The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0360500.1
– WD40 repeat-like protein; TAIR: AT1G27840.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q13216|ERCC8_HUMAN DNA excision repair protein ERCC-8; TrEMBL-Plants: tr|I1K866|I1K866_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0360500
Domains
17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00