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GO:0005673

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description Transcription factor TFIIE complex
Full defintion A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH.
Subterm of

Relationships

The relationship of GO:0005673 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCjl
PMID
Structure and oligomeric state of human transcription factor TFIIE.Jawhari A, Uhring M, De Carlo S, Crucifix C, Tocchini-Valentini G, Moras D, Schultz P, Poterszman A
EMBO Rep. 2006 May; 7 (5): 500–5.PMID: 16547462

The general RNA polymerase II transcription factor TFIIE, which is composed of two subunits, has essential roles in both transcription initiation and promoter escape. Electron microscopy analysis of negatively stained human TFIIE showed a large proportion of alpha/beta heterodimers as well as a small proportion of tetramers. Analytical ultracentrifugation, chemical crosslinking, pulldown experiments and cryo-electron microscopy confirmed that TFIIE is a alpha/beta heterodimer in solution. Three-dimensional envelopes of the alpha/beta particles showed an elongated structure composed of three distinct modules. Finally, a model for the quaternary architecture of the complex is proposed that provides a structural framework to discuss the function of TFIIE in the context of RNA polymerase II transcription initiation.

Associated Lotus transcripts 6

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj2g3v2017480.1
– General transcription factor IIE subunit [Medicago truncatula] gi|357481679|ref|XP_003611125.1|
GO terms
2
Lj4g3v2917640.1
– PREDICTED: general transcription factor IIE subunit 2-like [Glycine max] gi|356513413|ref|XP_003525408.1|
GO terms
2
LotjaGi2g1v0432600.1
– Transcription initiation factor IIE subunit beta; TAIR: AT4G20330.1 Transcription initiation factor TFIIE, beta subunit; Swiss-Prot: sp|P79011|T2EB_SCHPO Transcription initiation factor IIE subunit beta; TrEMBL-Plants: tr|I3SF72|I3SF72_LOTJA Transcription initiation factor IIE subunit beta; Found in the gene: LotjaGi2g1v0432600
GO terms
2
LotjaGi2g1v0432600.2
– Transcription initiation factor IIE subunit beta; TAIR: AT4G20330.1 Transcription initiation factor TFIIE, beta subunit; Swiss-Prot: sp|P79011|T2EB_SCHPO Transcription initiation factor IIE subunit beta; TrEMBL-Plants: tr|I3SF72|I3SF72_LOTJA Transcription initiation factor IIE subunit beta; Found in the gene: LotjaGi2g1v0432600
GO terms
2
LotjaGi4g1v0423600.1
– Transcription initiation factor IIE subunit beta; TAIR: AT4G20330.1 Transcription initiation factor TFIIE, beta subunit; Swiss-Prot: sp|Q54KJ8|T2EB_DICDI General transcription factor IIE subunit 2; TrEMBL-Plants: tr|A0A072TV28|A0A072TV28_MEDTR Transcription initiation factor TFIIE, beta subunit; Found in the gene: LotjaGi4g1v0423600
GO terms
2
LotjaGi4g1v0423600.2
– Transcription initiation factor IIE subunit beta; TAIR: AT4G20330.1 Transcription initiation factor TFIIE, beta subunit; Swiss-Prot: sp|Q54KJ8|T2EB_DICDI General transcription factor IIE subunit 2; TrEMBL-Plants: tr|A0A072TV28|A0A072TV28_MEDTR Transcription initiation factor TFIIE, beta subunit; Found in the gene: LotjaGi4g1v0423600
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0006367
Biological process Transcription initiation from RNA polymerase II promoter 1 16.67