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Field | Value |
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Namespace | Cellular component |
Short description | Epsilon DNA polymerase complex |
Full defintion | A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair. |
Subterm of |
The relationship of GO:0008622 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0008622, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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PMID | Eukaryotic DNA polymerases in DNA replication and DNA repair. Chromosoma. 1998 Sep; 107 (4): 218–27.PMID: 9745046 DNA polymerases carry out a large variety of synthetic transactions during DNA replication, DNA recombination and DNA repair. Substrates for DNA polymerases vary from single nucleotide gaps to kilobase size gaps and from relatively simple gapped structures to complex replication forks in which two strands need to be replicated simultaneously. Consequently, one would expect the cell to have developed a well-defined set of DNA polymerases with each one uniquely adapted for a specific pathway. And to some degree this turns out to be the case. However, in addition we seem to find a large degree of cross-functionality of DNA polymerases in these different pathways. DNA polymerase alpha is almost exclusively required for the initiation of DNA replication and the priming of Okazaki fragments during elongation. In most organisms no specific repair role beyond that of checkpoint control has been assigned to this enzyme. DNA polymerase delta functions as a dimer and, therefore, may be responsible for both leading and lagging strand DNA replication. In addition, this enzyme is required for mismatch repair and, together with DNA polymerase zeta, for mutagenesis. The function of DNA polymerase epsilon in DNA replication may be restricted to that of Okazaki fragment maturation. In contrast, either polymerase delta or epsilon suffices for the repair of UV-induced damage. The role of DNA polymerase beta in base-excision repair is well established for mammalian systems, but in yeast, DNA polymerase delta appears to fulfill that function. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: DNA polymerase epsilon subunit 2-like [Glycine max] gi|356560075|ref|XP_003548321.1| | 4 | ||
– | PREDICTED: DNA polymerase epsilon catalytic subunit A-like [Cicer arietinum] gi|502145356|ref|XP_004505995.1| | 5 | ||
– | PREDICTED: DNA polymerase epsilon catalytic subunit A-like [Cicer arietinum] gi|502145356|ref|XP_004505995.1| | 5 | ||
– | DNA polymerase epsilon subunit; TAIR: AT5G22110.1 DNA polymerase epsilon subunit B2; Swiss-Prot: sp|Q500V9|DPB2_ARATH DNA polymerase epsilon subunit B; TrEMBL-Plants: tr|A0A0L9VHK9|A0A0L9VHK9_PHAAN DNA polymerase epsilon subunit; Found in the gene: LotjaGi2g1v0185400 | 4 | ||
– | DNA polymerase epsilon subunit; TAIR: AT5G22110.1 DNA polymerase epsilon subunit B2; Swiss-Prot: sp|Q500V9|DPB2_ARATH DNA polymerase epsilon subunit B; TrEMBL-Plants: tr|A0A0L9VHK9|A0A0L9VHK9_PHAAN DNA polymerase epsilon subunit; Found in the gene: LotjaGi2g1v0185400 | 4 | ||
– | DNA polymerase epsilon subunit; TAIR: AT5G22110.1 DNA polymerase epsilon subunit B2; Swiss-Prot: sp|Q500V9|DPB2_ARATH DNA polymerase epsilon subunit B; TrEMBL-Plants: tr|A0A0L9VHK9|A0A0L9VHK9_PHAAN DNA polymerase epsilon subunit; Found in the gene: LotjaGi2g1v0185400 | 4 | ||
– | DNA polymerase epsilon subunit; TAIR: AT5G22110.1 DNA polymerase epsilon subunit B2; Swiss-Prot: sp|Q500V9|DPB2_ARATH DNA polymerase epsilon subunit B; TrEMBL-Plants: tr|A0A0L9VHK9|A0A0L9VHK9_PHAAN DNA polymerase epsilon subunit; Found in the gene: LotjaGi2g1v0185400 | 4 | ||
– | DNA polymerase epsilon, catalytic subunit, putative; TAIR: AT1G08260.1 DNA polymerase epsilon catalytic subunit; Swiss-Prot: sp|F4HW04|DPOE1_ARATH DNA polymerase epsilon catalytic subunit A; TrEMBL-Plants: tr|G7JKW4|G7JKW4_MEDTR DNA polymerase epsilon catalytic subunit A; Found in the gene: LotjaGi3g1v0479600 | 5 | ||
– | DNA polymerase epsilon catalytic subunit A; TAIR: AT1G08260.1 DNA polymerase epsilon catalytic subunit; Swiss-Prot: sp|F4HW04|DPOE1_ARATH DNA polymerase epsilon catalytic subunit A; TrEMBL-Plants: tr|G7JKW4|G7JKW4_MEDTR DNA polymerase epsilon catalytic subunit A; Found in the gene: LotjaGi3g1v0479600 | 5 | ||
– | DNA polymerase epsilon, catalytic subunit, putative; TAIR: AT1G08260.1 DNA polymerase epsilon catalytic subunit; Swiss-Prot: sp|F4HW04|DPOE1_ARATH DNA polymerase epsilon catalytic subunit A; TrEMBL-Plants: tr|G7JKW4|G7JKW4_MEDTR DNA polymerase epsilon catalytic subunit A; Found in the gene: LotjaGi3g1v0479600 | 5 | ||
– | DNA polymerase epsilon, catalytic subunit, putative; TAIR: AT1G08260.2 DNA polymerase epsilon catalytic subunit; Swiss-Prot: sp|F4HW04|DPOE1_ARATH DNA polymerase epsilon catalytic subunit A; TrEMBL-Plants: tr|G7JKW4|G7JKW4_MEDTR DNA polymerase epsilon catalytic subunit A; Found in the gene: LotjaGi3g1v0479600 | 5 | ||
– | DNA polymerase epsilon, catalytic subunit, putative; TAIR: AT1G08260.1 DNA polymerase epsilon catalytic subunit; Swiss-Prot: sp|F4HW04|DPOE1_ARATH DNA polymerase epsilon catalytic subunit A; TrEMBL-Plants: tr|G7JKW4|G7JKW4_MEDTR DNA polymerase epsilon catalytic subunit A; Found in the gene: LotjaGi3g1v0479600 | 5 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Cellular component | Epsilon DNA polymerase complex | 1 | 8.33 |