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Field | Value |
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Namespace | Cellular component |
Short description | TRNA (m1A) methyltransferase complex |
Full defintion | A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer. |
Subterm of |
The relationship of GO:0031515 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0031515, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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PMID | A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase. Nucleic Acids Res. 2004; 32 (2): 465–76.PMID: 14739239 The modified nucleoside 1-methyladenosine (m(1)A) is found in the T-loop of many tRNAs from organisms belonging to the three domains of life (Eukaryota, Bacteria, Archaea). In the T-loop of eukaryotic and bacterial tRNAs, m(1)A is present at position 58, whereas in archaeal tRNAs it is present at position(s) 58 and/or 57, m(1)A57 being the obligatory intermediate in the biosynthesis of 1-methylinosine (m(1)I57). In yeast, the formation of m(1)A58 is catalysed by the essential tRNA (m(1)A58) methyltransferase (MTase), a tetrameric enzyme that is composed of two types of subunits (Gcd14p and Gcd10p), whereas in the bacterium Thermus thermophilus the enzyme is a homotetramer of the TrmI polypeptide. Here, we report that the TrmI enzyme from the archaeon Pyrococcus abyssi is also a homotetramer. However, unlike the bacterial site-specific TrmI MTase, the P.abyssi enzyme is region-specific and catalyses the formation of m(1)A at two adjacent positions (57 and 58) in the T-loop of certain tRNAs. The stabilisation of P.abyssi TrmI at extreme temperatures involves intersubunit disulphide bridges that reinforce the tetrameric oligomerisation, as revealed by biochemical and crystallographic evidences. The origin and evolution of m(1)A MTases is discussed in the context of different hypotheses of the tree of life. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit trm6-like [Glycine max] gi|356562401|ref|XP_003549460.1| | 2 | ||
– | PREDICTED: tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit trm6-like [Glycine max] gi|356562401|ref|XP_003549460.1| | 2 | ||
– | Os04g0319600 [Oryza sativa Japonica Group] gi|297602457|ref|NP_001052454.2| | 3 | ||
– | PREDICTED: tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit trm6-like [Glycine max] gi|356562401|ref|XP_003549460.1| | 2 | ||
– | PREDICTED: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit trmt61a-like [Cicer arietinum] gi|502078105|ref|XP_004485841.1| | 3 | ||
– | PREDICTED: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit trmt61a-like [Cicer arietinum] gi|502078105|ref|XP_004485841.1| | 3 | ||
– | TRNA (Adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A; TAIR: AT5G14600.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q80XC2|TRM61_MOUSE tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; TrEMBL-Plants: tr|V7AKG9|V7AKG9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0270700 | 3 | ||
– | TRNA (Adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A; TAIR: AT5G14600.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q6AY46|TRM61_RAT tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; TrEMBL-Plants: tr|V7AKG9|V7AKG9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0036900 | 3 | ||
– | TRNA (Adenine(58)-N(1))-methyltransferase non-catalytic subunit trm6; TAIR: AT2G45730.1 eukaryotic initiation factor 3 gamma subunit family protein; Swiss-Prot: sp|Q54UB1|TRM6_DICDI tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit trm6; TrEMBL-Plants: tr|I1MY27|I1MY27_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0221400 | 2 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Cellular component | TRNA (m1A) methyltransferase complex | 1 | 11.11 |