Gene Ontology — View

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GO:0045116

Overview

Field	Value
Namespace	Biological process
Short description	Protein neddylation
Full defintion	Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
Subterm of	GO:0032446

Relationships

The relationship of GO:0045116 with other GO terms.

Relationship type	GO terms
Is a	GO:0032446
Regulates	n.a.
Part of	n.a.
Positively regulates	n.a.
Negatively regulates	n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0045116, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field	Value
PMID	A hitchhiker's guide to the proteasome.von Arnim AG Sci STKE. 2001 Aug 28; 2001 (97): pe2.PMID: 11698580 Regulated degradation of proteins is essential for viability and is involved in the control of many signal transduction pathways. von Arnim discusses a new model for how substrates destined for degradation by the 26S proteasome may be presented to the proteasome through a physical interaction between the proteasome and a complex consisting of the substrate and a ubiquitin-ligase. The new model suggests that the SCF (Skp1/cullin/F-box) protein complex may physically associate with the proteasome and that this interaction may be regulated by posttranslational modifications, such as phosphorylation or the covalent attachment of the Nedd8 protein, called neddylation. Additionally, other proteins may compete with the SCF complexes for binding to the proteasome and thus present another layer of regulation for controlling substrate targeting for ubiquitin-mediated degradation.

Field

Value

PMID

A hitchhiker's guide to the proteasome.von Arnim AG
Sci STKE. 2001 Aug 28; 2001 (97): pe2.PMID: 11698580

Regulated degradation of proteins is essential for viability and is involved in the control of many signal transduction pathways. von Arnim discusses a new model for how substrates destined for degradation by the 26S proteasome may be presented to the proteasome through a physical interaction between the proteasome and a complex consisting of the substrate and a ubiquitin-ligase. The new model suggests that the SCF (Skp1/cullin/F-box) protein complex may physically associate with the proteasome and that this interaction may be regulated by posttranslational modifications, such as phosphorylation or the covalent attachment of the Nedd8 protein, called neddylation. Additionally, other proteins may compete with the SCF complexes for binding to the proteasome and thus present another layer of regulation for controlling substrate targeting for ubiquitin-mediated degradation.

Associated Lotus transcripts 5

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Transcript	Name	Description	GO terms	GO count
Lj3g3v2906180.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	PREDICTED: NEDD8-activating enzyme E1 regulatory subunit-like [Glycine max] gi\|356517638\|ref\|XP_003527494.1\|	GO terms View details of GO:0019781 View details of GO:0045116	2
Lj4g3v2400830.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	PREDICTED: NEDD8-activating enzyme E1 catalytic subunit-like [Cicer arietinum] gi\|502149911\|ref\|XP_004507708.1\|	GO terms View details of GO:0019781 View details of GO:0045116	2
LotjaGi3g1v0466500.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	NEDD8-activating enzyme E1 regulatory subunit; TAIR: AT1G05180.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp\|P42744\|AXR1_ARATH NEDD8-activating enzyme E1 regulatory subunit AXR1; TrEMBL-Plants: tr\|I3SW23\|I3SW23_LOTJA NEDD8-activating enzyme E1 regulatory subunit; Found in the gene: LotjaGi3g1v0466500	GO terms View details of GO:0019781 View details of GO:0045116	2
LotjaGi3g1v0466500.2 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	NEDD8-activating enzyme E1 regulatory subunit; TAIR: AT1G05180.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp\|P42744\|AXR1_ARATH NEDD8-activating enzyme E1 regulatory subunit AXR1; TrEMBL-Plants: tr\|I3SW23\|I3SW23_LOTJA NEDD8-activating enzyme E1 regulatory subunit; Found in the gene: LotjaGi3g1v0466500	GO terms View details of GO:0019781 View details of GO:0045116	2
LotjaGi4g1v0352900.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	NEDD8-activating enzyme E1 catalytic subunit; TAIR: AT5G19180.1 E1 C-terminal related 1; Swiss-Prot: sp\|O65041\|UBA3_ARATH NEDD8-activating enzyme E1 catalytic subunit; TrEMBL-Plants: tr\|I1KNA2\|I1KNA2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0352900	GO terms View details of GO:0019781 View details of GO:0045116	2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term	Namespace	Name	Observations	Saturation (%)
GO:0045116 View details of GO:0045116 AmiGO InterPro QuickGO	Biological process	Protein neddylation	1	20.00