Gene Ontology — View

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GO:1990116

Overview

Field	Value
Namespace	Biological process
Short description	Ribosome-associated ubiquitin-dependent protein catabolic process
Full defintion	The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein.
Subterm of	GO:0043161

Relationships

The relationship of GO:1990116 with other GO terms.

Relationship type	GO terms
Is a	GO:0043161
Regulates	n.a.
Part of	n.a.
Positively regulates	n.a.
Negatively regulates	n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:1990116, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field	Value
GOC	dgf
PMID	Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.Verma R, Oania RS, Kolawa NJ, Deshaies RJ Elife. 2013 Jan 22; 2 (): e00308.PMID: 23358411 Ubiquitin-dependent proteolysis can initiate at ribosomes for myriad reasons including misfolding of a nascent chain or stalling of the ribosome during translation of mRNA. Clearance of a stalled complex is required to recycle the ribosome for future use. Here we show that the ubiquitin (Ub) pathway segregase Cdc48/p97 and its adaptors Ufd1-Npl4 participate in ribosome-associated degradation (RAD) by mediating the clearance of ubiquitinated, tRNA-linked nascent peptides from ribosomes. Through characterization of both endogenously-generated and heterologous model substrates for the RAD pathway, we conclude that budding yeast Cdc48 functions downstream of the Ub ligases Ltn1 and Ubr1 to release nascent proteins from the ribosome so that they can be degraded by the proteasome. Defective RAD could contribute to the pathophysiology of human diseases caused by mutations in p97.DOI:http://dx.doi.org/10.7554/eLife.00308.001.

Field

Value

GOC

dgf

PMID

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.Verma R, Oania RS, Kolawa NJ, Deshaies RJ
Elife. 2013 Jan 22; 2 (): e00308.PMID: 23358411

Ubiquitin-dependent proteolysis can initiate at ribosomes for myriad reasons including misfolding of a nascent chain or stalling of the ribosome during translation of mRNA. Clearance of a stalled complex is required to recycle the ribosome for future use. Here we show that the ubiquitin (Ub) pathway segregase Cdc48/p97 and its adaptors Ufd1-Npl4 participate in ribosome-associated degradation (RAD) by mediating the clearance of ubiquitinated, tRNA-linked nascent peptides from ribosomes. Through characterization of both endogenously-generated and heterologous model substrates for the RAD pathway, we conclude that budding yeast Cdc48 functions downstream of the Ub ligases Ltn1 and Ubr1 to release nascent proteins from the ribosome so that they can be degraded by the proteasome. Defective RAD could contribute to the pathophysiology of human diseases caused by mutations in p97.DOI:http://dx.doi.org/10.7554/eLife.00308.001.

Associated Lotus transcripts 2

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Transcript	Name	Description	GO terms	GO count
LotjaGi1g1v0111300.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	E3 ubiquitin-protein ligase listerin-like protein; TAIR: AT5G58410.2 HEAT/U-box domain-containing protein; Swiss-Prot: sp\|Q9FGI1\|LTN1_ARATH E3 ubiquitin-protein ligase listerin; TrEMBL-Plants: tr\|K7KAA3\|K7KAA3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0111300	GO terms View details of GO:0061630 View details of GO:1990112 View details of GO:1990116	3
LotjaGi1g1v0111300.2 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	E3 ubiquitin-protein ligase listerin-like protein; TAIR: AT5G58410.2 HEAT/U-box domain-containing protein; Swiss-Prot: sp\|Q9FGI1\|LTN1_ARATH E3 ubiquitin-protein ligase listerin; TrEMBL-Plants: tr\|K7KAA3\|K7KAA3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0111300	GO terms View details of GO:0061630 View details of GO:1990112 View details of GO:1990116	3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term	Namespace	Name	Observations	Saturation (%)
GO:1990116 View details of GO:1990116 AmiGO InterPro QuickGO	Biological process	Ribosome-associated ubiquitin-dependent protein catabolic process	1	50.00