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IPR000297 is a Peptidyl-prolyl cis-trans isomerase, PpiC-type.
<p>Peptidyl-prolyl cis-trans isomerase ([ec:5.2.1.8]) (PPIase or rotamase) is an enzyme that accelerates protein folding by catalysing the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides [[cite:PUB00000320]]. Most characterised PPiases belong to two families, the cyclophilin-type and the the FKBP-type. A third family has been discovered [[cite:PUB00001678]]. So far, the only biochemically characterised member of this family is the Escherichia coli protein parvulin (gene ppiC), a small (92 residues) cytoplasmic enzyme that prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates.</p> <p>This entry represents a conserved region that contains a serine which could play a role in the catalytic mechanism of these enzymes. This domain is present in Periplasmic chaperone PpiD that were originally thought to be peptidyl-prolyl isomerases but it was shown later that they lack such activity [[cite:PUB00097266]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Peptidyl-prolyl cis-trans isomerase activity | Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Parvulin-type peptidyl-prolyl cis/trans isomerase [Lotus japonicus] gi|152955223|emb|CAM59672.1| | 7 | ||
| – | Parvulin-type peptidyl prolyl cis/trans isomerase [Lotus japonicus] gi|152955225|emb|CAM59673.1| | 13 | ||
| – | Parvulin-type peptidyl-prolyl cis/trans isomerase [Lotus japonicus] gi|152955221|emb|CAM59671.1| | 10 | ||
| – | Peptidyl-prolyl cis-trans isomerase; TAIR: AT5G19370.1 rhodanese-like domain-containing protein / PPIC-type PPIASE domain-containing protein; Swiss-Prot: sp|Q93WI0|STR12_ARATH Rhodanese-like/PpiC domain-containing protein 12, chloroplastic; TrEMBL-Plants: tr|A7DX11|A7DX11_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0051200 | 15 | ||
| – | Peptidyl-prolyl cis-trans isomerase; TAIR: AT1G26550.1 FKBP-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q6P4K8|PIN4_XENTR Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; TrEMBL-Plants: tr|A7DX10|A7DX10_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0195000 | 9 | ||
| – | Peptidyl-prolyl cis-trans isomerase; TAIR: AT1G26550.1 FKBP-like peptidyl-prolyl cis-trans isomerase family protein; Swiss-Prot: sp|Q6P4K8|PIN4_XENTR Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; TrEMBL-Plants: tr|A7DX10|A7DX10_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi1g1v0195000 | 9 | ||
| – | Peptidyl-prolyl cis-trans isomerase; TAIR: AT2G18040.1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1; Swiss-Prot: sp|Q94G00|PIN1_MALDO Peptidyl-prolyl cis-trans isomerase Pin1; TrEMBL-Plants: tr|A7DX09|A7DX09_LOTJA Peptidyl-prolyl cis-trans isomerase; Found in the gene: LotjaGi4g1v0126600 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 14.29 |