Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR000447 is a FAD-dependent glycerol-3-phosphate dehydrogenase.
<p>FAD-dependent glycerol-3-phosphate dehydrogenase (G3PDH; [ec:1.1.5.3]) catalyses the conversion of glycerol-3-phosphate into dihydroxyacetone phosphate:</p> <p><reaction> sn-glycerol-3-phosphate + a quinone = glycerone phosphate + a quinol</reaction></p> <p>Insulin exposure often stimulates G3PDH activity [[cite:PUB00000242], [cite:PUB00001977]], and thus is key to reducing the effects of the disease diabetes. In obese people, where insulin resistance has been demonstrated, the amount of G3PDH has been shown to be correspondingly lower than that in normal weight people [[cite:PUB00000242]]. In bacteria [[cite:PUB00002130]] it is associated with the utilisation of glycerol coupled to respiration. In Escherichia coli and Haemophilus influenzae, two isozymes are known: one expressed under anaerobic conditions (gene glpA) and one in aerobic conditions (gene glpD). In eukaryotes, a mitochondrial form of GPD participates in the glycerol phosphate shuttle in conjunction with an NAD-dependent cytoplasmic GPD ([ec:1.1.1.8]) [[cite:PUB00005648], [cite:PUB00002843]]. This mechanism is responsible for the preservation of a redox balance [[cite:PUB00000544], [cite:PUB00005664]]. In this environment, the enzyme has been recorded to increase activity in the presence of calcium [[cite:PUB00000164]]. These enzymes are proteins of about 60 to 70 Kd which contain a probable FAD-binding domain in their N-terminal extremity. The mammalian enzyme differs from the bacterial or yeast proteins by having an EF-hand calcium-binding region (see [prositedoc:PDOC00018]) in its C-terminal extremity.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Glycerol-3-phosphate dehydrogenase (quinone) activity | Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. | ||
| Biological process | Glycerol-3-phosphate metabolic process | The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. | ||
| Cellular component | Glycerol-3-phosphate dehydrogenase complex | An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | 21 | |||
| – | Glycerol-3-phosphate dehydrogenase; TAIR: AT3G10370.1 FAD-dependent oxidoreductase family protein; Swiss-Prot: sp|Q9SS48|SDP6_ARATH Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial; TrEMBL-Plants: tr|I1LCX0|I1LCX0_SOYBN Glycerol-3-phosphate dehydrogenase; Found in the gene: LotjaGi5g1v0270500 | 24 | ||
| – | Glycerol-3-phosphate dehydrogenase; TAIR: AT3G10370.1 FAD-dependent oxidoreductase family protein; Swiss-Prot: sp|Q9SS48|SDP6_ARATH Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial; TrEMBL-Plants: tr|I1LCX0|I1LCX0_SOYBN Glycerol-3-phosphate dehydrogenase; Found in the gene: LotjaGi5g1v0270500 | 24 | ||
| – | Glycerol-3-phosphate dehydrogenase; TAIR: AT3G10370.1 FAD-dependent oxidoreductase family protein; Swiss-Prot: sp|Q9SS48|SDP6_ARATH Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial; TrEMBL-Plants: tr|I1LCX0|I1LCX0_SOYBN Glycerol-3-phosphate dehydrogenase; Found in the gene: LotjaGi5g1v0270500 | 24 | ||
| – | Glycerol-3-phosphate dehydrogenase; TAIR: AT3G10370.1 FAD-dependent oxidoreductase family protein; Swiss-Prot: sp|Q9SS48|SDP6_ARATH Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial; TrEMBL-Plants: tr|I1LCX0|I1LCX0_SOYBN Glycerol-3-phosphate dehydrogenase; Found in the gene: LotjaGi5g1v0270500 | 22 | ||
| – | Glycerol-3-phosphate dehydrogenase; TAIR: AT3G10370.1 FAD-dependent oxidoreductase family protein; Swiss-Prot: sp|Q9SS48|SDP6_ARATH Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial; TrEMBL-Plants: tr|I1LCX0|I1LCX0_SOYBN Glycerol-3-phosphate dehydrogenase; Found in the gene: LotjaGi5g1v0270500 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TMhelix | TMHMM | 1 | 16.67 |