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IPR000489 is a Pterin-binding domain.
<p>The ~250-residue pterin-binding domain has been shown to adopt a (β/α)8 barrel fold, which has the overall shape of a distorted cylinder. It has eight α-helices stacked around the outside of an inner cylinder of parallel β-strands. The pterin ring binds at the bottom of the (β/α)8 barrel in a polar cup-like region that is relatively solvent exposed and fairly negatively charged. The pterin ring is partially buried within the (β/α)8 barrel. The pterin binding residues are highly conserved and include aspartate and asparagine residues located at the C terminus of the β-strands of the barrel, which are predicted to form hydrogen bonds with the nitrogen and oxygen atoms of the pterin ring [[cite:PUB00014006], [cite:PUB00003947], [cite:PUB00018443]].</p> <p>Some proteins known to contain a pterin-binding domain are listed below:</p> <ul><li>Prokaryotic and eukaryotic B12-dependent methionine synthase (MetH) ([ec:2.1.1.13]), a large, modular protein that catalyses the transfer of a methyl group from methyltetrahydrofolate (CH3-H4folate) to Hcy to form methionine, using cobalamin as an intermediate methyl carrier.</li> <li>Prokaryotic and eukaryotic dihydropteroate synthase (DHPS) ([ec:2.5.1.15]). It catalyses the condensation of para-aminobenzoic acid (pABA) with 7,8-dihydropterin-pyrophosphate (DHPPP), eliminating pyrophosphate to form 7,8-dihydropteroate which is subsequently converted to tetrahydrofolate.</li> <li>Moorella thermoacetica 5-methyltetrahydrofolate corrinoid/iron sulphur protein methyltransferase (MeTr). It transfers the N5-methyl group from CH3-H4folate to a cob(I)amide centre in another protein, the corrinoid iron sulphur protein.</li></ul>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Pteridine-containing compound metabolic process | The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: folic acid synthesis protein fol1-like isoform X1 [Cicer arietinum] gi|502094412|ref|XP_004490212.1| | 12 | ||
| – | PREDICTED: folic acid synthesis protein fol1-like isoform X1 [Cicer arietinum] gi|502094412|ref|XP_004490212.1| | 20 | ||
| – | Dihydropteroate synthase, putative; TAIR: AT4G30000.1 Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Swiss-Prot: sp|O04862|FOLM_PEA Folate synthesis bifunctional protein, mitochondrial; TrEMBL-Plants: tr|G7JY17|G7JY17_MEDTR Dihydropterin pyrophosphokinase/dihydropteroate synthase; Found in the gene: LotjaGi2g1v0292900 | 21 | ||
| – | Dihydropteroate synthase, putative; TAIR: AT4G30000.1 Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Swiss-Prot: sp|O04862|FOLM_PEA Folate synthesis bifunctional protein, mitochondrial; TrEMBL-Plants: tr|G7JY17|G7JY17_MEDTR Dihydropterin pyrophosphokinase/dihydropteroate synthase; Found in the gene: LotjaGi2g1v0292900 | 21 | ||
| – | Dihydropteroate synthase, putative; TAIR: AT4G30000.1 Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Swiss-Prot: sp|O04862|FOLM_PEA Folate synthesis bifunctional protein, mitochondrial; TrEMBL-Plants: tr|A0A1J7HKC0|A0A1J7HKC0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0292900 | 21 | ||
| – | Dihydropteroate synthase, putative; TAIR: AT4G30000.1 Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Swiss-Prot: sp|O04862|FOLM_PEA Folate synthesis bifunctional protein, mitochondrial; TrEMBL-Plants: tr|A0A1J7HKC0|A0A1J7HKC0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0292900 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00739 | CDD | 1 | 16.67 |