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IPR006390 is a Dihydropteroate synthase domain.
<p>This domain is present in sequences representing dihydropteroate synthase, the enzyme that catalyzes the second to last step in folic acid biosynthesis.</p> <p>Dihydropteroate synthase ([ec:2.5.1.15]) (DHPS), a functional homodimer, catalyses the condensation of 6-hydroxymethyl-7,8-dihydropteridine pyrophosphate to para-aminobenzoic acid to form 7,8-dihydropteroate. This is the second step in the three-step pathway leading from 6-hydroxymethyl-7,8-dihydropterin to 7,8-dihydrofolate. DHPS is the target of sulfonamides, which are substrate analogues that compete with para-aminobenzoic acid. Bacterial DHPS (gene sul or folP) [[cite:PUB00002127]] is a protein of about 275 to 315 amino acid residues that is either chromosomally encoded or found on various antibiotic resistance plasmids. In the lower eukaryote Pneumocystis carinii, DHPS is the C-terminal domain of a multifunctional folate synthesis enzyme (gene fas) [[cite:PUB00001816]].</p> <p>Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Dihydropteroate synthase activity | Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. | ||
| Biological process | Folic acid-containing compound biosynthetic process | The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: folic acid synthesis protein fol1-like isoform X1 [Cicer arietinum] gi|502094412|ref|XP_004490212.1| | 20 | ||
| – | Dihydropteroate synthase, putative; TAIR: AT4G30000.1 Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Swiss-Prot: sp|O04862|FOLM_PEA Folate synthesis bifunctional protein, mitochondrial; TrEMBL-Plants: tr|G7JY17|G7JY17_MEDTR Dihydropterin pyrophosphokinase/dihydropteroate synthase; Found in the gene: LotjaGi2g1v0292900 | 21 | ||
| – | Dihydropteroate synthase, putative; TAIR: AT4G30000.1 Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Swiss-Prot: sp|O04862|FOLM_PEA Folate synthesis bifunctional protein, mitochondrial; TrEMBL-Plants: tr|G7JY17|G7JY17_MEDTR Dihydropterin pyrophosphokinase/dihydropteroate synthase; Found in the gene: LotjaGi2g1v0292900 | 21 | ||
| – | Dihydropteroate synthase, putative; TAIR: AT4G30000.1 Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Swiss-Prot: sp|O04862|FOLM_PEA Folate synthesis bifunctional protein, mitochondrial; TrEMBL-Plants: tr|A0A1J7HKC0|A0A1J7HKC0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0292900 | 21 | ||
| – | Dihydropteroate synthase, putative; TAIR: AT4G30000.1 Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Swiss-Prot: sp|O04862|FOLM_PEA Folate synthesis bifunctional protein, mitochondrial; TrEMBL-Plants: tr|A0A1J7HKC0|A0A1J7HKC0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0292900 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00739 | CDD | 1 | 20.00 |