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IPR011005 is a Dihydropteroate synthase-like superfamily.
<p>All organisms require reduced folate cofactors for the synthesis of a variety of metabolites. The enzyme 7,8-dihydropteroate synthase (DHPS) ([ec:2.5.1.15]) catalyses the condensation of para-aminobenzoic acid (pABA) with 6-hydroxymethyl-7, 8-dihydropterin-pyrophosphate to form 7,8-dihydropteroate and pyrophosphate. DHPS is essential for the de novo synthesis of folate in prokaryotes, lower eukaryotes, and in plants, but is absent in mammals [[cite:PUB00014005]]. By contrast, higher vertebrates possess an active transport system that enables them to use dietary folates. DHPS is the target of sulphonamides, which are substrate analogues that compete with pABA, but which do not affect vertebrates as they lack the DHPS enzyme. DHPS is a single domain protein that forms an eight-stranded TIM α/β barrel, where the 7,8-dihydropterin pyrophosphate substrate binds in a deep cleft in the barrel [[cite:PUB00003947]]. In the lower eukaryote Pneumocystis carinii, DHPS is the C-terminal domain of a multifunctional folate synthesis enzyme (gene fas) [[cite:PUB00001816]].</p> <p>Other proteins contain a DHPS-like domain, including members of the methyltetrahydrofolate (corrinoid iron-sulphur protein methyltransferase (MeTr)) family. MeTr catalyses a key step in the Wood-Ljungdahl pathway of carbon dioxide fixation [[cite:PUB00014006]]. Other members of this family that contain a DHPS-like domain include methionine synthase and methanogenic enzymes that activate the methyl group of methyltetrahydromethano(or -sarcino)pterin.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Cellular metabolic process | The chemical reactions and pathways by which individual cells transform chemical substances. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: folic acid synthesis protein fol1-like isoform X1 [Cicer arietinum] gi|502094412|ref|XP_004490212.1| | 20 | ||
| – | Dihydropteroate synthase, putative; TAIR: AT4G30000.1 Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Swiss-Prot: sp|O04862|FOLM_PEA Folate synthesis bifunctional protein, mitochondrial; TrEMBL-Plants: tr|G7JY17|G7JY17_MEDTR Dihydropterin pyrophosphokinase/dihydropteroate synthase; Found in the gene: LotjaGi2g1v0292900 | 21 | ||
| – | Dihydropteroate synthase, putative; TAIR: AT4G30000.1 Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Swiss-Prot: sp|O04862|FOLM_PEA Folate synthesis bifunctional protein, mitochondrial; TrEMBL-Plants: tr|G7JY17|G7JY17_MEDTR Dihydropterin pyrophosphokinase/dihydropteroate synthase; Found in the gene: LotjaGi2g1v0292900 | 21 | ||
| – | Dihydropteroate synthase, putative; TAIR: AT4G30000.1 Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Swiss-Prot: sp|O04862|FOLM_PEA Folate synthesis bifunctional protein, mitochondrial; TrEMBL-Plants: tr|A0A1J7HKC0|A0A1J7HKC0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0292900 | 21 | ||
| – | Dihydropteroate synthase, putative; TAIR: AT4G30000.1 Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Swiss-Prot: sp|O04862|FOLM_PEA Folate synthesis bifunctional protein, mitochondrial; TrEMBL-Plants: tr|A0A1J7HKC0|A0A1J7HKC0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0292900 | 21 | ||
| – | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|A0A151RCK5|A0A151RCK5_CAJCA 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Found in the gene: LotjaGi3g1v0162300 | 13 | ||
| – | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|A0A151RCK5|A0A151RCK5_CAJCA 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Found in the gene: LotjaGi3g1v0162300 | 13 | ||
| – | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|I1M4L1|I1M4L1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0162300 | 11 | ||
| – | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|A0A151RCK5|A0A151RCK5_CAJCA 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Found in the gene: LotjaGi3g1v0162300 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00612 | TIGRFAM | 1 | 11.11 |