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IPR000857 is a MyTH4 domain.
<p>The microtubule-based kinesin motors and actin-based myosin motors generate movements required for intracellular trafficking, cell division, and muscle contraction. In general, these proteins consist of a motor domain that generates movement and a tail region that varies widely from class to class and is thought to mediate many of the regulatory or cargo binding functions specific to each class of motor [[cite:PUB00015330]]. The Myosin Tail Homology 4 (MyTH4) domain has been identified as a conserved domain in the tail domains of several different unconventional myosins [[cite:PUB00015331]] and a plant kinesin-like protein [[cite:PUB00015332]], but has more recently been found in several non-motor proteins [[cite:PUB00015333]]. Although the function is not yet fully understood, there is an evidence that the MyTH4 domain of Myosin-X (Myo10) binds to microtubules and thus could provide a link between an actin-based motor protein and the microtubule cytoskeleton [[cite:PUB00015337]].</p> <p>The MyTH4 domain is found in one or two copies associated with other domains, such as myosin head, kinesin motor, FERM, PH, SH3 and IQ. The domain is predicted to be largely α-helical, interrupted by three or four turns. The MyTH4 domain contains four highly conserved regions designated MGD (consensus sequence L(K/R)(F/Y)MGDhP, LRDE (consensus LRDEhYCQhhKQHxxxN), RGW (consensus RGWxLh), and ELEA (RxxPPSxhELEA), where h indicates a hydrophobic residue and x is any residue [[cite:PUB00015331]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Cytoskeleton | Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: kinesin-like calmodulin-binding protein homolog [Glycine max] gi|356540898|ref|XP_003538921.1| | 7 | ||
| – | PREDICTED: kinesin-like calmodulin-binding protein homolog [Glycine max] gi|356540898|ref|XP_003538921.1| | 27 | ||
| – | Kinesin-like protein; TAIR: AT5G65930.2 kinesin-like calmodulin-binding protein (ZWICHEL); Swiss-Prot: sp|Q7XPJ0|KN14I_ORYSJ Kinesin-like protein KIN-14I; TrEMBL-Plants: tr|I1J891|I1J891_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0351000 | 44 | ||
| – | Kinesin-like protein; TAIR: AT5G65930.2 kinesin-like calmodulin-binding protein (ZWICHEL); Swiss-Prot: sp|Q7XPJ0|KN14I_ORYSJ Kinesin-like protein KIN-14I; TrEMBL-Plants: tr|I1J891|I1J891_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0351000 | 44 | ||
| – | Kinesin-like protein; TAIR: AT5G65930.2 kinesin-like calmodulin-binding protein (ZWICHEL); Swiss-Prot: sp|Q7XPJ0|KN14I_ORYSJ Kinesin-like protein KIN-14I; TrEMBL-Plants: tr|I1L4M5|I1L4M5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0141300 | 44 | ||
| – | Kinesin-like protein; TAIR: AT5G65930.2 kinesin-like calmodulin-binding protein (ZWICHEL); Swiss-Prot: sp|Q7XPJ0|KN14I_ORYSJ Kinesin-like protein KIN-14I; TrEMBL-Plants: tr|G7L7W2|G7L7W2_MEDTR Kinesin-like calmodulin-binding protein; Found in the gene: LotjaGi4g1v0141300 | 44 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |