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IPR014352 is a FERM/acyl-CoA-binding protein superfamily.
<p>This superfamily represents a structural domain with a core structure consisting of a 3-helical closed bundle with a left-handed twist, in an up-and-down arrangement. This structural motif occurs as subdomain 2 within FERM domains, as well as in acyl-CoA-binding proteins. The FERM domain (band F ezrin-radixin-moesin homology domains) has such a structure, acting as a common membrane-binding module involved in localising proteins to the plasma membrane [[cite:PUB00013213]]. Proteins containing FERM include cytoskeletal proteins such as erythrocyte membrane protein 4.1R, talin, and the ezrin-radixin-moesin protein family, as well as several protein tyrosine kinases and phosphatases, and the neurofibromatosis 2 tumour suppressor protein merlin. The ezrin-radixin-moesin protein family function is to crosslink the actin filaments of cytoskeletal structures to the plasma membrane.</p> <p>In addition, acyl-CoA-binding protein (ACBP) contains a domain with a similar 3-helical bundle structure. ACBP plays an important role in fatty acid metabolism, maintaining a pool of fatty acyl-CoA molecules in the cell [[cite:PUB00021736]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: acyl-CoA-binding domain-containing protein 2-like [Glycine max] gi|356509224|ref|XP_003523351.1| | 24 | ||
| – | PREDICTED: kinesin-like calmodulin-binding protein homolog [Glycine max] gi|356531307|ref|XP_003534219.1| | 28 | ||
| – | Acyl-CoA-binding protein [Camellia sinensis] gi|330318654|gb|AEC10987.1| | 12 | ||
| – | PREDICTED: kinesin-like calmodulin-binding protein homolog [Glycine max] gi|356540898|ref|XP_003538921.1| | 27 | ||
| – | PREDICTED: acyl-CoA-binding domain-containing protein 3-like [Cicer arietinum] gi|502125647|ref|XP_004499010.1| | 15 | ||
| – | PREDICTED: acyl-CoA-binding domain-containing protein 3-like [Cicer arietinum] gi|502125647|ref|XP_004499010.1| | 16 | ||
| – | Acyl-CoA-binding domain-containing protein [Medicago truncatula] gi|357511945|ref|XP_003626261.1| | 6 | ||
| – | Acyl-CoA-binding domain protein; TAIR: AT4G27780.1 acyl-CoA binding protein 2; Swiss-Prot: sp|Q9STP8|ACBP2_ARATH Acyl-CoA-binding domain-containing protein 2; TrEMBL-Plants: tr|I1KAV2|I1KAV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0289200 | 25 | ||
| – | Kinesin-like protein; TAIR: AT5G65930.2 kinesin-like calmodulin-binding protein (ZWICHEL); Swiss-Prot: sp|Q7XPJ0|KN14I_ORYSJ Kinesin-like protein KIN-14I; TrEMBL-Plants: tr|I1J891|I1J891_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0351000 | 44 | ||
| – | Kinesin-like protein; TAIR: AT5G65930.2 kinesin-like calmodulin-binding protein (ZWICHEL); Swiss-Prot: sp|Q7XPJ0|KN14I_ORYSJ Kinesin-like protein KIN-14I; TrEMBL-Plants: tr|I1J891|I1J891_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0351000 | 44 | ||
| – | Kinesin-like protein; TAIR: AT5G65930.2 kinesin-like calmodulin-binding protein (ZWICHEL); Swiss-Prot: sp|Q7XPJ0|KN14I_ORYSJ Kinesin-like protein KIN-14I; TrEMBL-Plants: tr|I1L4M5|I1L4M5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0141300 | 44 | ||
| – | Kinesin-like protein; TAIR: AT5G65930.2 kinesin-like calmodulin-binding protein (ZWICHEL); Swiss-Prot: sp|Q7XPJ0|KN14I_ORYSJ Kinesin-like protein KIN-14I; TrEMBL-Plants: tr|G7L7W2|G7L7W2_MEDTR Kinesin-like calmodulin-binding protein; Found in the gene: LotjaGi4g1v0141300 | 44 | ||
| – | Acyl-CoA-binding domain protein; TAIR: AT4G24230.6 acyl-CoA-binding domain 3; Swiss-Prot: sp|Q9STX1|ACBP3_ARATH Acyl-CoA-binding domain-containing protein 3; TrEMBL-Plants: tr|A0A072VPF6|A0A072VPF6_MEDTR Acyl-CoA-binding domain protein; Found in the gene: LotjaGi5g1v0032200 | 16 | ||
| – | Acyl-CoA-binding domain protein; TAIR: AT4G24230.6 acyl-CoA-binding domain 3; Swiss-Prot: sp|Q9STX1|ACBP3_ARATH Acyl-CoA-binding domain-containing protein 3; TrEMBL-Plants: tr|A0A072VPF6|A0A072VPF6_MEDTR Acyl-CoA-binding domain protein; Found in the gene: LotjaGi5g1v0032200 | 17 | ||
| – | Acyl-CoA-binding domain-containing protein 4; TAIR: AT3G05420.2 acyl-CoA binding protein 4; Swiss-Prot: sp|Q9MA55|ACBP4_ARATH Acyl-CoA-binding domain-containing protein 4; TrEMBL-Plants: tr|A0A0B2QFE8|A0A0B2QFE8_GLYSO Acyl-CoA-binding domain-containing protein 4; Found in the gene: LotjaGi5g1v0222400 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 6.67 |