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IPR001059 is a Translation elongation factor P/YeiP, central.
<p>Elongation factor P (EF-P) is a prokaryotic protein translation factor required for efficient peptide bond synthesis on 70S ribosomes from fMet-tRNAfMet [[cite:PUB00000702], [cite:PUB00081045]]. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-tRNA and puromycine in vitro. EF-P binds to both the 30S and 50S ribosomal subunits. EF-P binds near the streptomycine binding site of the 16S rRNA in the 30S subunit. EF-P interacts with domains 2 and 5 of the 23S rRNA. The L16 ribosomal protein of the 50S or its N-terminal fragment are required for EF-P mediated peptide bond synthesis, whereas L11, L15, and L7/L12 are not required in this reaction, suggesting that EF-P may function at a different ribosomal site than most other translation factors. EF-P is essential for cell viability and is required for protein synthesis. EF-P is mainly present in bacteria. The EF-P homologs in archaea and eukaryotes are the initiation factors aIF5A and eIF5A, respectively.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Translation elongation factor activity | Functions in chain elongation during polypeptide synthesis at the ribosome. | ||
| Biological process | Translational elongation | The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: elongation factor P-like [Cicer arietinum] gi|502134670|ref|XP_004502202.1| | 8 | ||
| – | PREDICTED: elongation factor P-like [Cicer arietinum] gi|502104488|ref|XP_004492556.1| | 20 | ||
| – | PREDICTED: elongation factor P-like [Cicer arietinum] gi|502104488|ref|XP_004492556.1| | 30 | ||
| – | Elongation factor P; TAIR: AT3G08740.1 elongation factor P (EF-P) family protein; Swiss-Prot: sp|Q54760|EFP_SYNE7 Elongation factor P; TrEMBL-Plants: tr|I3T3T8|I3T3T8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0456600 | 31 | ||
| – | Elongation factor P; TAIR: AT4G26310.1 elongation factor P (EF-P) family protein; Swiss-Prot: sp|A4YTY9|EFP_BRASO Elongation factor P; TrEMBL-Plants: tr|A0A0L9T427|A0A0L9T427_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0031100 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |