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IPR001171 is a Sterol biosynthesis ERG24/DHCR-like.
<p>This entry represents a group of enzymes involved in the steroid biosynthetic pathway, including 7-dehydrocholesterol reductase and Delta(14)-sterol reductase LBR (lamin B receptor) from animals [[cite:PUB00100221], [cite:PUB00100217], [cite:PUB00100220]], Delta(14)-sterol reductase from fungi and plants [[cite:PUB00100218], [cite:PUB00100219], [cite:PUB00100216]] and Delta(24(24(1)))-sterol reductase from yeast [[cite:PUB00001844]]. These proteins act by reducing double bonds in precursors of ergosterol, are highly hydrophobic and seem to contain seven or eight transmembrane regions.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | ||
| Biological process | Sterol biosynthetic process | The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. | ||
| Molecular function | Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Ergosterol biosynthesis ERG4/ERG24 family isoform 1 [Theobroma cacao] gi|508716214|gb|EOY08111.1| | 2 | ||
| – | PREDICTED: delta(14)-sterol reductase-like [Fragaria vesca subsp]. vesca] gi|470134380|ref|XP_004303031.1| | 2 | ||
| – | PREDICTED: 7-dehydrocholesterol reductase-like [Fragaria vesca subsp]. vesca] gi|470136049|ref|XP_004303814.1| | 10 | ||
| – | PREDICTED: delta(14)-sterol reductase-like [Cicer arietinum] gi|502122143|ref|XP_004497600.1| | 9 | ||
| – | PREDICTED: delta(14)-sterol reductase-like [Cicer arietinum] gi|502122143|ref|XP_004497600.1| | 10 | ||
| – | 7-dehydrocholesterol reductase; TAIR: AT1G50430.1 Ergosterol biosynthesis ERG4/ERG24 family; Swiss-Prot: sp|Q9LDU6|ST7R_ARATH 7-dehydrocholesterol reductase; TrEMBL-Plants: tr|V7AQL6|V7AQL6_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0342200 | 12 | ||
| – | Sterol delta-7 reductase; TAIR: AT1G50430.2 Ergosterol biosynthesis ERG4/ERG24 family; Swiss-Prot: sp|Q9LDU6|ST7R_ARATH 7-dehydrocholesterol reductase; TrEMBL-Plants: tr|A0A072UFJ5|A0A072UFJ5_MEDTR 7-dehydrocholesterol reductase-like protein; Found in the gene: LotjaGi3g1v0342200 | 11 | ||
| – | 7-dehydrocholesterol reductase; TAIR: AT1G50430.1 Ergosterol biosynthesis ERG4/ERG24 family; Swiss-Prot: sp|Q9LDU6|ST7R_ARATH 7-dehydrocholesterol reductase; TrEMBL-Plants: tr|A0A0S3T0X2|A0A0S3T0X2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0342200 | 17 | ||
| – | 7-dehydrocholesterol reductase, putative; TAIR: AT1G50430.1 Ergosterol biosynthesis ERG4/ERG24 family; Swiss-Prot: sp|Q9LDU6|ST7R_ARATH 7-dehydrocholesterol reductase; TrEMBL-Plants: tr|A0A0S3T0X2|A0A0S3T0X2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0342200 | 10 | ||
| – | Delta(14)-sterol reductase; TAIR: AT3G52940.1 Ergosterol biosynthesis ERG4/ERG24 family; Swiss-Prot: sp|Q9LDR4|ERG24_ARATH Delta(14)-sterol reductase; TrEMBL-Plants: tr|V7BHD4|V7BHD4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0090700 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 10.00 |