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IPR018083

Source: InterPro

Description

IPR018083 is a Sterol reductase, conserved site.

<p>The following enzymes belong to a conserved family of sterol reductases which act by reducing double bonds [[cite:PUB00001844], [cite:PUB00018010]]:</p> <ul> <li>Fungal delta(14)-sterol reductase ([ec:1.3.1.70]) (C-14 sterol reductase) (gene ERG24 in budding yeast), an enzyme of ergosterol biosynthesis.</li> <li>Mammalian (TM7SF2) and plant delta(14)-sterol reductases.</li> <li>Fungal delta(24(24(1)))-sterol reductase ([ec:1.3.1.71]) (C-24(28) sterol reductase) (gene ERG4 in budding yeast), an enzyme of ergosterol biosynthesis.</li> <li>Mammalian 7-dehydrocholesterol reductase ([ec:1.3.1.21]) which produces cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7- DHC).</li> <li>Lamin B receptor, which is thought to anchor the lamina to the inner nuclear membrane.</li> </ul> <p>All these proteins are highly hydrophobic and seem to contain seven or eight transmembrane regions.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016628
Molecular function Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 8

Transcript Name Description Predicted domains Domain count
Lj3g3v2039890.1
– PREDICTED: 7-dehydrocholesterol reductase-like [Fragaria vesca subsp]. vesca] gi|470136049|ref|XP_004303814.1|
Domains
10
Lj5g3v0709800.1
– PREDICTED: delta(14)-sterol reductase-like [Cicer arietinum] gi|502122143|ref|XP_004497600.1|
Domains
9
Lj5g3v0709800.2
– PREDICTED: delta(14)-sterol reductase-like [Cicer arietinum] gi|502122143|ref|XP_004497600.1|
Domains
10
LotjaGi3g1v0342200.1
– 7-dehydrocholesterol reductase; TAIR: AT1G50430.1 Ergosterol biosynthesis ERG4/ERG24 family; Swiss-Prot: sp|Q9LDU6|ST7R_ARATH 7-dehydrocholesterol reductase; TrEMBL-Plants: tr|V7AQL6|V7AQL6_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0342200
Domains
12
LotjaGi3g1v0342200.2
– Sterol delta-7 reductase; TAIR: AT1G50430.2 Ergosterol biosynthesis ERG4/ERG24 family; Swiss-Prot: sp|Q9LDU6|ST7R_ARATH 7-dehydrocholesterol reductase; TrEMBL-Plants: tr|A0A072UFJ5|A0A072UFJ5_MEDTR 7-dehydrocholesterol reductase-like protein; Found in the gene: LotjaGi3g1v0342200
Domains
11
LotjaGi3g1v0342200.3
– 7-dehydrocholesterol reductase; TAIR: AT1G50430.1 Ergosterol biosynthesis ERG4/ERG24 family; Swiss-Prot: sp|Q9LDU6|ST7R_ARATH 7-dehydrocholesterol reductase; TrEMBL-Plants: tr|A0A0S3T0X2|A0A0S3T0X2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0342200
Domains
17
LotjaGi3g1v0342200.4
– 7-dehydrocholesterol reductase, putative; TAIR: AT1G50430.1 Ergosterol biosynthesis ERG4/ERG24 family; Swiss-Prot: sp|Q9LDU6|ST7R_ARATH 7-dehydrocholesterol reductase; TrEMBL-Plants: tr|A0A0S3T0X2|A0A0S3T0X2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0342200
Domains
10
LotjaGi5g1v0090700.1
– Delta(14)-sterol reductase; TAIR: AT3G52940.1 Ergosterol biosynthesis ERG4/ERG24 family; Swiss-Prot: sp|Q9LDR4|ERG24_ARATH Delta(14)-sterol reductase; TrEMBL-Plants: tr|V7BHD4|V7BHD4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0090700
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 12.50