Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR001469 is a ATP synthase, F1 complex, delta/epsilon subunit.
<p>This family represents subunits called delta (in mitochondrial ATPase) or epsilon (in bacteria or chloroplast ATPase). The interaction site of subunit C of the F0 complex with the delta or epsilon subunit of the F1 complex may be important for connecting the rotor of F1 (gamma subunit) to the rotor of F0 (C subunit) [[cite:PUB00020606]]. In bacterial species, the delta subunit is the equivalent of the Oligomycin sensitive subunit (OSCP, [interpro:IPR000711]) in metazoans. The C-terminal domain of the epsilon subunit appears to act as an inhibitor of ATPase activity [[cite:PUB00035968]].</p> <p>Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP.</p> <p>F-ATPases (also known as ATP synthases, F1F0-ATPase, or H(+)-transporting two-sector ATPase) ([ec:7.1.2.2]) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha, beta, gamma, delta, epsilon), while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C), with additional subunits in mitochondria. Both the F1 and F0 complexes are rotary motors that are coupled back-to-back. In the F1 complex, the central gamma subunit forms the rotor inside the cylinder made of the α(3)β(3) subunits, while in the F0 complex, the ring-shaped C subunits forms the rotor. The two rotors rotate in opposite directions, but the F0 rotor is usually stronger, using the force from the proton gradient to push the F1 rotor in reverse in order to drive ATP synthesis [[cite:PUB00009752]]. These ATPases can also work in reverse in bacteria, hydrolysing ATP to create a proton gradient.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | ATP synthesis coupled proton transport | The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. | ||
| Cellular component | Proton-transporting ATP synthase complex, catalytic core F(1) | The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. | ||
| Molecular function | Proton-transporting ATP synthase activity, rotational mechanism | Enables the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ATP synthase subunit delta', mitochondrial-like [Cicer arietinum] gi|502182788|ref|XP_004516996.1| | 4 | ||
| – | PREDICTED: ATP synthase subunit delta', mitochondrial-like [Glycine max] gi|356504527|ref|XP_003521047.1| | 12 | ||
| – | ATP synthase epsilon chain; TAIR: AT5G47030.1 ATPase, F1 complex, delta/epsilon subunit; Swiss-Prot: sp|Q41000|ATP4_PEA ATP synthase subunit delta', mitochondrial; TrEMBL-Plants: tr|I3SW31|I3SW31_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0071200 | 13 | ||
| – | ATP synthase subunit beta; TAIR: ATCG00480.1 ATP synthase subunit beta (ChrC); Swiss-Prot: sp|Q4VZI5|ATPB_CUCSA ATP synthase subunit beta, chloroplastic; TrEMBL-Plants: tr|M0ZKF0|M0ZKF0_SOLTU Uncharacterized protein; Found in the gene: LotjaGi4g1v0210300 | 21 | ||
| – | ATP synthase subunit beta; TAIR: ATCG00480.1 ATP synthase subunit beta (ChrC); Swiss-Prot: sp|Q4VZI5|ATPB_CUCSA ATP synthase subunit beta, chloroplastic; TrEMBL-Plants: tr|M0ZKF0|M0ZKF0_SOLTU Uncharacterized protein; Found in the gene: LotjaGi4g1v0210300 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd18110 | CDD | 1 | 20.00 |