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IPR001474

Source: InterPro

Description

IPR001474 is a GTP cyclohydrolase I.

<p>GTP cyclohydrolase I ([ec:3.5.4.16]) catalyses the biosynthesis of formic acid and dihydroneopterin triphosphate from GTP [[cite:PUB00022220]]. This reaction is the first step in the biosynthesis of tetrahydrofolate in prokaryotes, of tetrahydrobiopterin in vertebrates, and of pteridine-containing pigments in insects. The comparison of the sequence of the enzyme from bacterial and eukaryotic sources shows that the structure of this enzyme has been extremely well conserved throughout evolution [[cite:PUB00000247]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003934
Molecular function GTP cyclohydrolase I activity Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
Subterm of
GO:0046654
Biological process Tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
Subterm of

Associated Lotus transcripts 8

Transcript Name Description Predicted domains Domain count
Lj1g3v3580540.1
– GTP cyclohydrolase I [Medicago truncatula] gi|357505161|ref|XP_003622869.1|
Domains
8
Lj3g3v0718700.1
– GTP cyclohydrolase I [Medicago truncatula] gi|357505161|ref|XP_003622869.1|
Domains
8
Lj3g3v0718710.1
– GTP cyclohydrolase I [Medicago truncatula] gi|357505161|ref|XP_003622869.1|
Domains
8
LotjaGi1g1v0591900_LC.1
– GTP cyclohydrolase 1; TAIR: AT3G07270.1 GTP cyclohydrolase I; Swiss-Prot: sp|Q8VYU3|GCH1_SOLLC GTP cyclohydrolase 1; TrEMBL-Plants: tr|K7MSK2|K7MSK2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0591900_LC
Domains
10
LotjaGi1g1v0591900_LC.2
– GTP cyclohydrolase 1; TAIR: AT3G07270.1 GTP cyclohydrolase I; Swiss-Prot: sp|Q8VYU3|GCH1_SOLLC GTP cyclohydrolase 1; TrEMBL-Plants: tr|I3T069|I3T069_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0591900_LC
Domains
8
LotjaGi1g1v0591900_LC.3
– GTP cyclohydrolase 1; TAIR: AT3G07270.1 GTP cyclohydrolase I; Swiss-Prot: sp|Q8VYU3|GCH1_SOLLC GTP cyclohydrolase 1; TrEMBL-Plants: tr|K7MSK2|K7MSK2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0591900_LC
Domains
10
LotjaGi1g1v0591900_LC.4
– GTP cyclohydrolase 1; TAIR: AT3G07270.1 GTP cyclohydrolase I; Swiss-Prot: sp|Q8VYU3|GCH1_SOLLC GTP cyclohydrolase 1; TrEMBL-Plants: tr|I3T069|I3T069_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0591900_LC
Domains
8
LotjaGi3g1v0087600.1
– GTP cyclohydrolase 1; TAIR: AT3G07270.1 GTP cyclohydrolase I; Swiss-Prot: sp|Q8VYU3|GCH1_SOLLC GTP cyclohydrolase 1; TrEMBL-Plants: tr|A0A072TL11|A0A072TL11_MEDTR GTP cyclohydrolase I 1; Found in the gene: LotjaGi3g1v0087600
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF55620 SUPERFAMILY 1 12.50