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IPR043134

Source: InterPro

Description

IPR043134 is a GTP cyclohydrolase I, N-terminal domain.

<p>GTP cyclohydrolase I ([ec:3.5.4.16]) catalyses the biosynthesis of formic acid and dihydroneopterin triphosphate from GTP [[cite:PUB00022220]]. This reaction is the first step in the biosynthesis of tetrahydrofolate in prokaryotes, of tetrahydrobiopterin in vertebrates, and of pteridine-containing pigments in insects. The comparison of the sequence of the enzyme from bacterial and eukaryotic sources shows that the structure of this enzyme has been extremely well conserved throughout evolution [[cite:PUB00000247]].</p> <p>This superfamily entry consists of the N-terminal domain found in GTP cyclohydrolases I (GTP-CH-I), which has been well conserved throughout evolution across bacterial and eukaryotic species. The GTP-CH-I monomer folds into an α β structure with a predominantly helical N-terminal part [[cite:PUB00005261]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0591900_LC.1
– GTP cyclohydrolase 1; TAIR: AT3G07270.1 GTP cyclohydrolase I; Swiss-Prot: sp|Q8VYU3|GCH1_SOLLC GTP cyclohydrolase 1; TrEMBL-Plants: tr|K7MSK2|K7MSK2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0591900_LC
Domains
10
LotjaGi1g1v0591900_LC.3
– GTP cyclohydrolase 1; TAIR: AT3G07270.1 GTP cyclohydrolase I; Swiss-Prot: sp|Q8VYU3|GCH1_SOLLC GTP cyclohydrolase 1; TrEMBL-Plants: tr|K7MSK2|K7MSK2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0591900_LC
Domains
10
LotjaGi3g1v0087600.1
– GTP cyclohydrolase 1; TAIR: AT3G07270.1 GTP cyclohydrolase I; Swiss-Prot: sp|Q8VYU3|GCH1_SOLLC GTP cyclohydrolase 1; TrEMBL-Plants: tr|A0A072TL11|A0A072TL11_MEDTR GTP cyclohydrolase I 1; Found in the gene: LotjaGi3g1v0087600
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF55620 SUPERFAMILY 1 33.33