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IPR001920

Source: InterPro

Description

IPR001920 is a Asp/Glu racemase.

<p>Aspartate racemase ([ec:5.1.1.13]) and glutamate racemase ([ec:5.1.1.3]) are two evolutionary related bacterial enzymes that do not seem to require a cofactor for their activity [[cite:PUB00000380]]. Glutamate racemase catalyses the interconversion of d-and l-glutamic acid and is the source of d-glutamate in most bacterial strains. d-Glutamic acid is an important biosynthetic building block since it is required in the formation of peptidoglycan that protects bacteria from osmotic lysis. Two conserved cysteines are present in the sequence of these enzymes. They are expected to play a role in catalytic activity by acting as bases in proton abstraction from the substrate [[cite:PUB00083403], [cite:PUB00083404]].</p> <p>Glutamate racemase forms a dimer and each monomer consists of two α/β fold domains [[cite:PUB00023532]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016855
Molecular function Racemase and epimerase activity, acting on amino acids and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid.
Subterm of

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj3g3v0075760.1
– PREDICTED: probable amino-acid racemase-like [Glycine max] gi|356557255|ref|XP_003546933.1|
Domains
7
Lj3g3v2224710.1
– PREDICTED: probable amino-acid racemase-like [Cicer arietinum] gi|502080821|ref|XP_004486690.1|
Domains
7
LotjaGi3g1v0011400.1
– Aspartate racemase; TAIR: AT1G15410.1 aspartate-glutamate racemase family; Swiss-Prot: sp|O58403|RACD_PYRHO Aspartate racemase; TrEMBL-Plants: tr|Q2HVX3|Q2HVX3_MEDTR Asp/Glu racemase; Found in the gene: LotjaGi3g1v0011400
Domains
8
LotjaGi3g1v0359000.1
– Aspartate racemase; TAIR: AT1G15410.1 aspartate-glutamate racemase family; Swiss-Prot: sp|O58403|RACD_PYRHO Aspartate racemase; TrEMBL-Plants: tr|I1M5S1|I1M5S1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0359000
Domains
8
LotjaGi4g1v0268800.1
– Aspartate racemase; TAIR: AT1G15410.1 aspartate-glutamate racemase family; Swiss-Prot: sp|O58403|RACD_PYRHO Aspartate racemase; TrEMBL-Plants: tr|A0A0L9TSD3|A0A0L9TSD3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0268800
Domains
7
LotjaGi4g1v0268800.2
– Aspartate racemase; TAIR: AT1G15410.1 aspartate-glutamate racemase family; Swiss-Prot: sp|O58403|RACD_PYRHO Aspartate racemase; TrEMBL-Plants: tr|A0A0L9TSD3|A0A0L9TSD3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0268800
Domains
7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF53681 SUPERFAMILY 1 16.67