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IPR002008 is a DNA polymerase family X, beta-like.
<p>DNA carries the biological information that instructs cells how to exist in an ordered fashion: accurate replication is thus one of the most important events in the cell life cycle. This function is mediated by DNA-directed DNA-polymerases, which add nucleotide triphosphate (dNTP) residues to the 3'-end of the growing DNA chain, using a complementary DNA as template. Small RNA molecules are generally used as primers for chain elongation, although terminal proteins may also be used. Three motifs, A, B and C [[cite:PUB00004955]], are seen to be conserved across all DNA-polymerases, with motifs A and C also seen in RNA- polymerases. They are centred on invariant residues, and their structural significance was implied from the Klenow (Escherichia coli) structure: motif A contains a strictly-conserved aspartate at the junction of a β-strand and an α-helix; motif B contains an α-helix with positive charges; and motif C has a doublet of negative charges, located in a β-turn-β secondary structure [[cite:PUB00004955]].</p> <p>DNA polymerases ([ec:2.7.7.7]) can be classified, on the basis of sequence similarity [[cite:PUB00004647], [cite:PUB00004955]], into at least four different groups: A, B, C and X. Members of family X are small (about 40kDa) compared with other polymerases and encompass two distinct polymerase enzymes that have similar functionality: vertebrate polymerase beta (same as yeast pol 4), and terminal deoxynucleotidyl-transferase (TdT) ([ec:2.7.7.31]). The former functions in DNA repair, while the latter terminally adds single nucleotides to polydeoxynucleotide chains. Both enzymes catalyse addition of nucleotides in a distributive manner, i.e. they dissociate from the template-primer after addition of each nucleotide. DNA-polymerases show a degree of structural similarity with RNA-polymerases.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA polymerase lambda-like isoform X1 [Cicer arietinum] gi|502181313|ref|XP_004516776.1| | 32 | ||
| – | DNA polymerase lambda; TAIR: AT1G10520.1 DNA polymerase lambda (POLL); Swiss-Prot: sp|Q9FNY4|DPOLL_ARATH DNA polymerase lambda; TrEMBL-Plants: tr|I1JCZ1|I1JCZ1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0314500 | 30 | ||
| – | DNA polymerase lambda-like protein; TAIR: AT1G10520.1 DNA polymerase lambda (POLL); Swiss-Prot: sp|Q9FNY4|DPOLL_ARATH DNA polymerase lambda; TrEMBL-Plants: tr|A0A072TY09|A0A072TY09_MEDTR DNA polymerase lambda-like protein; Found in the gene: LotjaGi2g1v0314500 | 36 | ||
| – | DNA polymerase lambda-like protein; TAIR: AT1G10520.1 DNA polymerase lambda (POLL); Swiss-Prot: sp|Q9FNY4|DPOLL_ARATH DNA polymerase lambda; TrEMBL-Plants: tr|A0A072TY09|A0A072TY09_MEDTR DNA polymerase lambda-like protein; Found in the gene: LotjaGi2g1v0314500 | 36 | ||
| – | DNA polymerase lambda; TAIR: AT1G10520.1 DNA polymerase lambda (POLL); Swiss-Prot: sp|Q9FNY4|DPOLL_ARATH DNA polymerase lambda; TrEMBL-Plants: tr|I1JCZ1|I1JCZ1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0314500 | 37 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |