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IPR001357

Source: InterPro

Description

IPR001357 is a BRCT domain.

<p>The breast cancer susceptibility gene contains at its C terminus two copies of a conserved domain that was named BRCT for BRCA1 C terminus. This domain of about 95 amino acids is found in a large variety of proteins involved in DNA repair, recombination and cell cycle control [[cite:PUB00003902], [cite:PUB00001533], [cite:PUB00001703]]. The BRCT domain is not limited to the C-terminal of protein sequences and can be found in multiple copies or in a single copy as in RAP1 and TdT. BRCT domains are often found as tandem-repeat pairs [[cite:PUB00094292]]. Some data [[cite:PUB00001320]] indicate that the BRCT domain functions as a protein-protein interaction module.</p> <p>The structure of the first of the two C-terminal BRCT domains of the human DNA repair protein XRCC1 has been determined by X-ray crystallography [[cite:PUB00001320]].</p> <p>Structures of the BRCA1 BRCT domains revealed a basis for a widely utilised head-to-tail BRCT-BRCT oligomerization mode [[cite:PUB00026458]]. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants [[cite:PUB00031299]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 63

Transcript Name Description Predicted domains Domain count
Lj0g3v0116489.1
– Uncharacterized protein isoform 1 [Theobroma cacao] gi|508727720|gb|EOY19617.1|
Domains
8
Lj0g3v0205999.1
– PREDICTED: RNA polymerase II C-terminal domain phosphatase-like 4-like isoform X1 [Cicer arietinum] gi|502149960|ref|XP_004507725.1|
Domains
9
Lj0g3v0217409.1
– PREDICTED: DNA topoisomerase 2-binding protein 1-A-like [Glycine max] gi|356560149|ref|XP_003548358.1|
Domains
12
Lj0g3v0217409.2
– PREDICTED: DNA topoisomerase 2-binding protein 1-A-like [Glycine max] gi|356560149|ref|XP_003548358.1|
Domains
12
Lj0g3v0245549.1
– Uncharacterized protein isoform 3 [Theobroma cacao] gi|508727722|gb|EOY19619.1|
Domains
7
Lj0g3v0294399.1
– PREDICTED: protein BREAST CANCER SUSCEPTIBILITY 1 homolog [Cicer arietinum] gi|502110153|ref|XP_004493812.1|
Domains
22
Lj0g3v0315339.1
– Zinc finger family protein [Arabidopsis lyrata subsp]. lyrata] gi|297838453|ref|XP_002887108.1|
Domains
10
Lj0g3v0359589.1
– PREDICTED: DNA repair protein REV1-like isoform X2 [Cicer arietinum] gi|502158837|ref|XP_004511297.1|
Domains
25
Lj1g3v0049850.1
– PREDICTED: DNA repair protein REV1-like isoform X2 [Cicer arietinum] gi|502158837|ref|XP_004511297.1|
Domains
25
Lj1g3v0627680.1
– PREDICTED: DNA polymerase lambda-like isoform X1 [Cicer arietinum] gi|502181313|ref|XP_004516776.1|
Domains
32
Lj1g3v1788440.1
– DNA topoisomerase 2-binding protein [Medicago truncatula] gi|357465905|ref|XP_003603237.1|
Domains
9
Lj1g3v1932550.1
– PREDICTED: pescadillo homolog isoform X2 [Cicer arietinum] gi|502154817|ref|XP_004509849.1|
Domains
14
Lj1g3v3137940.1
– PREDICTED: RNA polymerase II C-terminal domain phosphatase-like 3-like [Glycine max] gi|356523718|ref|XP_003530482.1|
Domains
19
Lj1g3v4225550.1
– GCN5-related N-acetyltransferase; BRCT [Medicago truncatula] gi|87241454|gb|ABD33312.1|
Domains
14
Lj1g3v4225550.2
– GCN5-related N-acetyltransferase; BRCT [Medicago truncatula] gi|87241454|gb|ABD33312.1|
Domains
14
Lj1g3v4483410.1
– PREDICTED: poly [ADP]-ribose] gi|502109943|ref|XP_004493762.1|
Domains
29
Lj1g3v4764360.1
– Mediator of DNA damage checkpoint protein [Medicago truncatula] gi|357466939|ref|XP_003603754.1|
Domains
8
Lj2g3v0866680.1
– DNA topoisomerase 2-binding protein [Medicago truncatula] gi|357465905|ref|XP_003603237.1|
Domains
9
Lj2g3v1510660.1
– PREDICTED: poly [ADP]-ribose] gi|502109943|ref|XP_004493762.1|
Domains
37
Lj2g3v3187350.1
– Pescadillo-like protein [Medicago truncatula] gi|357510461|ref|XP_003625519.1|
Domains
9
Lj3g3v0139460.1
– PREDICTED: DNA repair protein XRCC1-like [Cicer arietinum] gi|502080899|ref|XP_004486715.1|
Domains
9
Lj3g3v2926310.3
– PREDICTED: replication factor C subunit 1-like [Glycine max] gi|356517673|ref|XP_003527511.1|
Domains
19
Lj3g3v2995640.1
– RecName: Full=Putative poly [ADP]-ribose] gi|118573101|sp|Q1SGF1.1|PARP3_MEDTR
Domains
28
Lj5g3v1600740.1
– BRCT domain-containing protein [Medicago truncatula] gi|357442293|ref|XP_003591424.1|
Domains
20
Lj6g3v1916100.1
– Mediator of DNA damage checkpoint protein [Medicago truncatula] gi|357447487|ref|XP_003594019.1|
Domains
10
Lj6g3v1946520.1
– PREDICTED: protein BREAST CANCER SUSCEPTIBILITY 1 homolog [Glycine max] gi|356557797|ref|XP_003547197.1|
Domains
14
LotjaGi1g1v0026600.1
– Pescadillo homolog; TAIR: AT5G14520.1 pescadillo-like protein; Swiss-Prot: sp|Q9LYK7|PESC_ARATH Pescadillo homolog; TrEMBL-Plants: tr|A0A151TB86|A0A151TB86_CAJCA Pescadillo homolog; Found in the gene: LotjaGi1g1v0026600
Domains
15
LotjaGi1g1v0157100.1
– DNA topoisomerase 2-binding 1; TAIR: AT1G77320.3 transcription coactivator; Swiss-Prot: sp|Q6ZQF0|TOPB1_MOUSE DNA topoisomerase 2-binding protein 1; TrEMBL-Plants: tr|A0A0R0FVP4|A0A0R0FVP4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0157100
Domains
11
LotjaGi1g1v0157100.2
– DNA topoisomerase 2-binding protein 1; TAIR: AT1G77320.1 transcription coactivator; Swiss-Prot: sp|Q800K6|TOB1A_XENLA DNA topoisomerase 2-binding protein 1-A; TrEMBL-Plants: tr|A0A0R0FVP4|A0A0R0FVP4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0157100
Domains
15
LotjaGi1g1v0372400_LC.1
– BRCT domain DNA repair protein; TAIR: AT2G26270.1 BRCT domain DNA repair protein; Swiss-Prot: sp|Q2YR11|MNME_BRUA2 tRNA modification GTPase MnmE; TrEMBL-Plants: tr|I3S499|I3S499_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0372400_LC
Domains
4
LotjaGi1g1v0372400_LC.2
– BRCT domain DNA repair protein; TAIR: AT2G26270.1 BRCT domain DNA repair protein; Swiss-Prot: sp|Q2YR11|MNME_BRUA2 tRNA modification GTPase MnmE; TrEMBL-Plants: tr|I3S499|I3S499_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0372400_LC
Domains
4
LotjaGi1g1v0372400_LC.3
– BRCT domain DNA repair protein; TAIR: AT2G26270.1 BRCT domain DNA repair protein; Swiss-Prot: sp|Q2YR11|MNME_BRUA2 tRNA modification GTPase MnmE; TrEMBL-Plants: tr|I3S499|I3S499_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0372400_LC
Domains
4
LotjaGi1g1v0372400_LC.4
– BRCT domain DNA repair protein; TAIR: AT2G26270.1 BRCT domain DNA repair protein; Swiss-Prot: sp|Q2YR11|MNME_BRUA2 tRNA modification GTPase MnmE; TrEMBL-Plants: tr|I3S499|I3S499_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0372400_LC
Domains
4
LotjaGi1g1v0390500.1
– Pescadillo homolog; TAIR: AT5G14520.1 pescadillo-like protein; Swiss-Prot: sp|Q9LYK7|PESC_ARATH Pescadillo homolog; TrEMBL-Plants: tr|A0A151TB86|A0A151TB86_CAJCA Pescadillo homolog; Found in the gene: LotjaGi1g1v0390500
Domains
15
LotjaGi1g1v0529200.1
– RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT2G33540.1 C-terminal domain phosphatase-like 3; Swiss-Prot: sp|Q8LL04|CPL3_ARATH RNA polymerase II C-terminal domain phosphatase-like 3; TrEMBL-Plants: tr|I1KWR8|I1KWR8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0529200
Domains
24
LotjaGi1g1v0668900.1
– PAX-interacting protein 1; TAIR: AT2G41450.1 N-acetyltransferase; Swiss-Prot: sp|Q6ZW49|PAXI1_HUMAN PAX-interacting protein 1; TrEMBL-Plants: tr|K7KER9|K7KER9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0668900
Domains
16
LotjaGi1g1v0705900.1
– Breast cancer associated RING 1; TAIR: AT1G04020.1 breast cancer associated RING 1; Swiss-Prot: sp|F4I443|BARD1_ARATH BRCA1-associated RING domain protein 1; TrEMBL-Plants: tr|A0A0B2PNV8|A0A0B2PNV8_GLYSO Protein BREAST CANCER SUSCEPTIBILITY 1 like; Found in the gene: LotjaGi1g1v0705900
Domains
27
LotjaGi1g1v0711100.1
– Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi1g1v0711100
Domains
46
LotjaGi1g1v0711100.2
– Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi1g1v0711100
Domains
45
LotjaGi1g1v0711100.3
– Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi1g1v0711100
Domains
45
LotjaGi1g1v0744300_LC.1
– PAX-interacting protein 1; TAIR: AT4G03130.1 BRCT domain-containing DNA repair protein; Swiss-Prot: sp|Q6ZW49|PAXI1_HUMAN PAX-interacting protein 1; TrEMBL-Plants: tr|K7MZF3|K7MZF3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0744300_LC
Domains
12
LotjaGi2g1v0251700.1
– RING/U-box protein; TAIR: AT1G67180.1 zinc finger (C3HC4-type RING finger) family protein / BRCT domain-containing protein; Swiss-Prot: sp|O04251|Y4211_ARATH BRCT domain-containing protein At4g02110; TrEMBL-Plants: tr|I1N6L6|I1N6L6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0251700
Domains
20
LotjaGi2g1v0314500.2
– DNA polymerase lambda-like protein; TAIR: AT1G10520.1 DNA polymerase lambda (POLL); Swiss-Prot: sp|Q9FNY4|DPOLL_ARATH DNA polymerase lambda; TrEMBL-Plants: tr|A0A072TY09|A0A072TY09_MEDTR DNA polymerase lambda-like protein; Found in the gene: LotjaGi2g1v0314500
Domains
36
LotjaGi2g1v0314500.3
– DNA polymerase lambda-like protein; TAIR: AT1G10520.1 DNA polymerase lambda (POLL); Swiss-Prot: sp|Q9FNY4|DPOLL_ARATH DNA polymerase lambda; TrEMBL-Plants: tr|A0A072TY09|A0A072TY09_MEDTR DNA polymerase lambda-like protein; Found in the gene: LotjaGi2g1v0314500
Domains
36
LotjaGi2g1v0314500.4
– DNA polymerase lambda; TAIR: AT1G10520.1 DNA polymerase lambda (POLL); Swiss-Prot: sp|Q9FNY4|DPOLL_ARATH DNA polymerase lambda; TrEMBL-Plants: tr|I1JCZ1|I1JCZ1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0314500
Domains
37
LotjaGi2g1v0337700.1
– Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi2g1v0337700
Domains
45
LotjaGi2g1v0337700.2
– Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi2g1v0337700
Domains
40
LotjaGi2g1v0461300.1
– DNA polymerase IV; TAIR: AT5G44750.1 DNA-directed DNA polymerase; Swiss-Prot: sp|A3EWL3|REV1_ARATH DNA repair protein REV1; TrEMBL-Plants: tr|A0A0R0LQ66|A0A0R0LQ66_SOYBN DNA repair protein REV1; Found in the gene: LotjaGi2g1v0461300
Domains
29
LotjaGi2g1v0461300.2
– DNA polymerase IV; TAIR: AT5G44750.1 DNA-directed DNA polymerase; Swiss-Prot: sp|A3EWL3|REV1_ARATH DNA repair protein REV1; TrEMBL-Plants: tr|A0A0R0LQ66|A0A0R0LQ66_SOYBN DNA repair protein REV1; Found in the gene: LotjaGi2g1v0461300
Domains
29
LotjaGi2g1v0461300.3
– DNA polymerase IV; TAIR: AT5G44750.1 DNA-directed DNA polymerase; Swiss-Prot: sp|A3EWL3|REV1_ARATH DNA repair protein REV1; TrEMBL-Plants: tr|A0A0R0LQ66|A0A0R0LQ66_SOYBN DNA repair protein REV1; Found in the gene: LotjaGi2g1v0461300
Domains
26
LotjaGi3g1v0014900.1
– DNA repair protein XRCC1; TAIR: AT1G80420.1 BRCT domain-containing DNA repair protein; Swiss-Prot: sp|Q24JK4|XRCC1_ARATH DNA-repair protein XRCC1; TrEMBL-Plants: tr|I1M5N0|I1M5N0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0014900
Domains
11
LotjaGi3g1v0106700.1
– BRCT domain-containing protein; TAIR: AT4G02110.2 transcription coactivator; Swiss-Prot: sp|O70445|BARD1_MOUSE BRCA1-associated RING domain protein 1; TrEMBL-Plants: tr|V7BUV1|V7BUV1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0106700
Domains
10
LotjaGi3g1v0478100.1
– Poly [ADP]-ribose] polymerase; TAIR: AT5G22470.1 poly ADP-ribose polymerase 3; Swiss-Prot: sp|Q9SWB4|PARP3_SOYBN Poly [ADP]-ribose] polymerase 3; TrEMBL-Plants: tr|G7JIG7|G7JIG7_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi3g1v0478100
Domains
38
LotjaGi3g1v0478100.2
– Poly [ADP]-ribose] polymerase; TAIR: AT5G22470.1 poly ADP-ribose polymerase 3; Swiss-Prot: sp|Q9SWB4|PARP3_SOYBN Poly [ADP]-ribose] polymerase 3; TrEMBL-Plants: tr|G7JIG7|G7JIG7_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi3g1v0478100
Domains
34
LotjaGi4g1v0203800_LC.1
– Poly [adp]-ribose] polymerase 1; TAIR: AT1G67180.6 zinc finger (C3HC4-type RING finger) family protein / BRCT domain-containing protein; Swiss-Prot: sp|O04251|Y4211_ARATH BRCT domain-containing protein At4g02110; TrEMBL-Plants: tr|I3SQR6|I3SQR6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0203800_LC
Domains
10
LotjaGi4g1v0287100.1
– RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.1 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|V7BX02|V7BX02_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0287100
Domains
23
LotjaGi4g1v0287100.2
– RNA polymerase II C-terminal domain phosphatase-like protein; TAIR: AT5G58003.1 C-terminal domain phosphatase-like 4; Swiss-Prot: sp|Q00IB6|CPL4_ARATH RNA polymerase II C-terminal domain phosphatase-like 4; TrEMBL-Plants: tr|A0A0L9TRV4|A0A0L9TRV4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0287100
Domains
22
LotjaGi5g1v0246200.1
– BRCT domain-containing protein family; TAIR: AT4G02110.2 transcription coactivator; Swiss-Prot: sp|O04251|Y4211_ARATH BRCT domain-containing protein At4g02110; TrEMBL-Plants: tr|A0A072VP53|A0A072VP53_MEDTR DNA replication regulator dpb11, putative; Found in the gene: LotjaGi5g1v0246200
Domains
23
LotjaGi5g1v0246200.2
– BRCT domain-containing protein family; TAIR: AT4G02110.2 transcription coactivator; Swiss-Prot: sp|O04251|Y4211_ARATH BRCT domain-containing protein At4g02110; TrEMBL-Plants: tr|A0A072VP53|A0A072VP53_MEDTR DNA replication regulator dpb11, putative; Found in the gene: LotjaGi5g1v0246200
Domains
24
LotjaGi6g1v0235200.1
– DNA ligase; TAIR: AT5G57160.2 DNA ligase IV; Swiss-Prot: sp|Q9LL84|DNLI4_ARATH DNA ligase 4; TrEMBL-Plants: tr|K7MBU8|K7MBU8_SOYBN DNA ligase; Found in the gene: LotjaGi6g1v0235200
Domains
26
LotjaGi6g1v0235200.2
– DNA ligase; TAIR: AT5G57160.1 DNA ligase IV; Swiss-Prot: sp|Q9LL84|DNLI4_ARATH DNA ligase 4; TrEMBL-Plants: tr|K7MBU8|K7MBU8_SOYBN DNA ligase; Found in the gene: LotjaGi6g1v0235200
Domains
36
LotjaGi6g1v0304700.1
– PAX-interacting protein 1; TAIR: AT3G21480.1 BRCT domain-containing DNA repair protein; Swiss-Prot: sp|A0JNA8|PAXI1_BOVIN PAX-interacting protein 1; TrEMBL-Plants: tr|K7MAL7|K7MAL7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0304700
Domains
13
LotjaGi6g1v0312100_LC.1
– Breast cancer associated RING 1; TAIR: AT4G21070.1 breast cancer susceptibility1; Swiss-Prot: sp|Q8RXD4|BRCA1_ARATH Protein BREAST CANCER SUSCEPTIBILITY 1 homolog; TrEMBL-Plants: tr|V7BPN4|V7BPN4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0312100_LC
Domains
30

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 1.59