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IPR002415 is a H/ACA ribonucleoprotein complex, subunit Nhp2-like.
<p>This entry represents H/ACA ribonucleoprotein complex subunit NHP2 and similar proteins from eukaryotes, including NHP2-like protein 1 from mammals (SNU13 homologue) and 13 kDa ribonucleoprotein-associated protein (SNU13) from yeast.</p> <p>Nhp2 is part of a complex which catalyses pseudouridylation of rRNA and is required for rRNA biogenesis. This involves the isomerisation of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilise the conformation of rRNAs. Nph2 associates non-specifically with RNA secondary structures instead of directly binding to an specific RNA motif. This protein seem to have evolved from the archaeal ribosomal L7Ae protein family [[cite:PUB00099951]].</p> <p>H/ACA ribonucleoprotein particles (RNPs) are a family of RNA pseudouridine synthases that specify modification sites through guide RNAs. The function of these H/ACA RNPs is essential for biogenesis of the ribosome, splicing of precursor mRNAs (pre-mRNAs), maintenance of telomeres and probably for additional cellular processes [[cite:PUB00053435]]. All H/ACA RNPs contain a specific RNA component (snoRNA or scaRNA) and at least four proteins common to all such particles: Cbf5, Gar1, Nhp2 and Nop10. These proteins are highly conserved from yeast to mammals and homologues are also present in archaea [[cite:PUB00088317]]. The H/ACA protein complex contains a stable core composed of Cbf5 and Nop10, to which Gar1 and Nhp2 subsequently bind [[cite:PUB00053436]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | ||
| Cellular component | Nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: NHP2-like protein 1-like [Cicer arietinum] gi|502087441|ref|XP_004488534.1| | 13 | ||
| – | PREDICTED: NHP2-like protein 1-like [Cicer arietinum] gi|502087441|ref|XP_004488534.1| | 14 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: H/ACA ribonucleoprotein complex subunit 2-like protein-like [Glycine max] gi|356511577|ref|XP_003524501.1| | 11 | ||
| – | Ribosomal protein l7ae; TAIR: AT4G22380.1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein; Swiss-Prot: sp|Q5XH16|NH2L1_XENLA NHP2-like protein 1; TrEMBL-Plants: tr|I3SXG0|I3SXG0_MEDTR Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein; Found in the gene: LotjaGi1g1v0200100 | 14 | ||
| – | H/ACA ribonucleoprotein complex subunit 2-like protein; TAIR: AT5G08180.1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein; Swiss-Prot: sp|Q9LEY9|NHP2_ARATH H/ACA ribonucleoprotein complex subunit 2-like protein; TrEMBL-Plants: tr|I3T6V7|I3T6V7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0259200 | 11 | ||
| – | H/ACA ribonucleoprotein complex subunit 2-like protein; TAIR: AT5G08180.1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein; Swiss-Prot: sp|Q9LEY9|NHP2_ARATH H/ACA ribonucleoprotein complex subunit 2-like protein; TrEMBL-Plants: tr|I3T6V7|I3T6V7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0259200 | 11 | ||
| – | Ribosomal protein l7ae; TAIR: AT5G20160.2 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein; Swiss-Prot: sp|Q5XH16|NH2L1_XENLA NHP2-like protein 1; TrEMBL-Plants: tr|I3T354|I3T354_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0162200 | 14 | ||
| – | Ribosomal protein l7ae; TAIR: AT5G20160.2 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein; Swiss-Prot: sp|Q5XH16|NH2L1_XENLA NHP2-like protein 1; TrEMBL-Plants: tr|I3T354|I3T354_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0162200 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF55315 | SUPERFAMILY | 1 | 12.50 |