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IPR002550 is a CNNM, transmembrane domain.
<p>Proteins containing the ancient conserved domain protein/cyclin M (CNNM) are integral membrane proteins that are conserved from bacteria to humans. CNNM family members influence metal ion homeostasis through mechanisms that may not involve direct membrane transport of the ions. Structurally, CNNMs are complex proteins that contain an extracellular N-terminal domain preceding a transmembrane domain, a "Bateman module", which consists of two cystathionine-beta-synthase (CBS) domains, and a C-terminal cNMP (cyclic nucleotide monophosphate) binding domain [[cite:PUB00088668], [cite:PUB00088669], [cite:PUB00088670], [cite:PUB00088671], [cite:PUB00098586]].</p> <p>The CNNM transmembrane domain contains four hydrophobic regions and forms a dimer through hydrophobic contacts between TM2 and TM3, in which each chain is composed of three transmembrane helices (TM1-3), a pair of short helices exposed on the intracellular side, and a juxtamembrane (JM) helix that forms a belt-like structure [[cite:PUB00088669], [cite:PUB00098586]]. The homodimer adopts an inward-facing conformation with a negatively charged cavity containing a conserved pi-helical turn in TM3 that coordinates a Mg2 ion [[cite:PUB00098586]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DUF21 domain-containing protein At1g55930, chloroplastic-like [Glycine max] gi|356553522|ref|XP_003545104.1| | 9 | ||
| – | PREDICTED: DUF21 domain-containing protein At4g14240-like [Fragaria vesca subsp]. vesca] gi|470108753|ref|XP_004290673.1| | 15 | ||
| – | PREDICTED: DUF21 domain-containing protein At4g14240-like [Fragaria vesca subsp]. vesca] gi|470108753|ref|XP_004290673.1| | 11 | ||
| – | PREDICTED: DUF21 domain-containing protein At1g55930, chloroplastic-like [Glycine max] gi|356553522|ref|XP_003545104.1| | 9 | ||
| – | PREDICTED: DUF21 domain-containing protein At2g14520-like [Glycine max] gi|356524776|ref|XP_003531004.1| | 13 | ||
| – | PREDICTED: DUF21 domain-containing protein At4g14240-like [Glycine max] gi|356521943|ref|XP_003529609.1| | 14 | ||
| – | PREDICTED: DUF21 domain-containing protein At1g47330-like isoform X1 [Cicer arietinum] gi|502131534|ref|XP_004501015.1| | 8 | ||
| – | PREDICTED: DUF21 domain-containing protein At1g47330-like isoform X1 [Cicer arietinum] gi|502131534|ref|XP_004501015.1| | 14 | ||
| – | PREDICTED: DUF21 domain-containing protein At5g52790-like [Glycine max] gi|356561500|ref|XP_003549019.1| | 13 | ||
| – | PREDICTED: DUF21 domain-containing protein At4g14240-like [Glycine max] gi|356557879|ref|XP_003547237.1| | 14 | ||
| – | DUF21 domain-containing protein; TAIR: AT1G55930.1 CBS domain-containing protein / transporter associated domain-containing protein; Swiss-Prot: sp|Q84R21|Y1559_ARATH DUF21 domain-containing protein At1g55930, chloroplastic; TrEMBL-Plants: tr|I1M6I6|I1M6I6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0019100 | 22 | ||
| – | DUF21 domain-containing protein; TAIR: AT1G55930.1 CBS domain-containing protein / transporter associated domain-containing protein; Swiss-Prot: sp|Q84R21|Y1559_ARATH DUF21 domain-containing protein At1g55930, chloroplastic; TrEMBL-Plants: tr|I1M6I6|I1M6I6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0019100 | 26 | ||
| – | DUF21 domain-containing protein; TAIR: AT1G47330.1 methyltransferase, putative (DUF21); Swiss-Prot: sp|Q8RY60|Y1733_ARATH DUF21 domain-containing protein At1g47330; TrEMBL-Plants: tr|A0A072V458|A0A072V458_MEDTR CBS domain protein; Found in the gene: LotjaGi1g1v0418900 | 14 | ||
| – | DUF21 domain-containing-like protein; TAIR: AT1G03270.1 CBS domain protein with a domain protein (DUF21); Swiss-Prot: sp|Q9ZVS8|Y1327_ARATH Putative DUF21 domain-containing protein At1g03270; TrEMBL-Plants: tr|A0A0R0ENY0|A0A0R0ENY0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0729500 | 14 | ||
| – | DUF21 domain-containing protein; TAIR: AT5G52790.1 CBS domain protein with a domain protein (DUF21); Swiss-Prot: sp|Q9LTD8|Y5279_ARATH DUF21 domain-containing protein At5g52790; TrEMBL-Plants: tr|K7LDK6|K7LDK6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0126000 | 12 | ||
| – | DUF21 domain-containing protein; TAIR: AT5G52790.2 CBS domain protein with a domain protein (DUF21); Swiss-Prot: sp|Q9LTD8|Y5279_ARATH DUF21 domain-containing protein At5g52790; TrEMBL-Plants: tr|K7LDK6|K7LDK6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0126000 | 12 | ||
| – | DUF21 domain-containing protein; TAIR: AT5G52790.1 CBS domain protein with a domain protein (DUF21); Swiss-Prot: sp|Q9LTD8|Y5279_ARATH DUF21 domain-containing protein At5g52790; TrEMBL-Plants: tr|K7MI04|K7MI04_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0126500 | 12 | ||
| – | DUF21 domain-containing protein; TAIR: AT4G33700.1 CBS domain protein (DUF21); Swiss-Prot: sp|Q8VZI2|Y4370_ARATH DUF21 domain-containing protein At4g33700; TrEMBL-Plants: tr|A0A0L9TL72|A0A0L9TL72_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0044100 | 13 | ||
| – | DUF21 domain-containing protein; TAIR: AT2G14520.1 CBS domain protein (DUF21); Swiss-Prot: sp|Q9ZQR4|Y2452_ARATH DUF21 domain-containing protein At2g14520; TrEMBL-Plants: tr|I1KQU1|I1KQU1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0044100 | 13 | ||
| – | DUF21 domain-containing protein; TAIR: AT2G14520.1 CBS domain protein (DUF21); Swiss-Prot: sp|Q9ZQR4|Y2452_ARATH DUF21 domain-containing protein At2g14520; TrEMBL-Plants: tr|I1KQU1|I1KQU1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0044100 | 14 | ||
| – | DUF21 domain-containing protein; TAIR: AT2G14520.1 CBS domain protein (DUF21); Swiss-Prot: sp|Q9ZQR4|Y2452_ARATH DUF21 domain-containing protein At2g14520; TrEMBL-Plants: tr|I1KQU0|I1KQU0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0044100 | 14 | ||
| – | DUF21 domain-containing protein; TAIR: AT2G14520.1 CBS domain protein (DUF21); Swiss-Prot: sp|Q9ZQR4|Y2452_ARATH DUF21 domain-containing protein At2g14520; TrEMBL-Plants: tr|A0A0L9TL72|A0A0L9TL72_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0044100 | 12 | ||
| – | DUF21 domain-containing protein; TAIR: AT4G14240.1 CBS domain protein with a domain protein (DUF21); Swiss-Prot: sp|Q67XQ0|Y4424_ARATH DUF21 domain-containing protein At4g14240; TrEMBL-Plants: tr|I1KN82|I1KN82_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0351200 | 14 | ||
| – | DUF21 domain-containing protein; TAIR: AT1G55930.1 CBS domain-containing protein / transporter associated domain-containing protein; Swiss-Prot: sp|Q84R21|Y1559_ARATH DUF21 domain-containing protein At1g55930, chloroplastic; TrEMBL-Plants: tr|I1M6I6|I1M6I6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0148300 | 23 | ||
| – | DUF21 domain-containing protein; TAIR: AT1G55930.1 CBS domain-containing protein / transporter associated domain-containing protein; Swiss-Prot: sp|Q84R21|Y1559_ARATH DUF21 domain-containing protein At1g55930, chloroplastic; TrEMBL-Plants: tr|K7KBK9|K7KBK9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0148300 | 22 | ||
| – | DUF21 domain-containing protein; TAIR: AT4G14240.1 CBS domain protein with a domain protein (DUF21); Swiss-Prot: sp|Q67XQ0|Y4424_ARATH DUF21 domain-containing protein At4g14240; TrEMBL-Plants: tr|I1MFD9|I1MFD9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0299200 | 14 | ||
| – | DUF21 domain-containing protein; TAIR: AT4G14240.1 CBS domain protein with a domain protein (DUF21); Swiss-Prot: sp|Q67XQ0|Y4424_ARATH DUF21 domain-containing protein At4g14240; TrEMBL-Plants: tr|A0A151U0Q8|A0A151U0Q8_CAJCA Protein MAM3; Found in the gene: LotjaGi6g1v0299200 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 3.70 |