Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR002657 is a Bile acid:sodium symporter/arsenical resistance protein Acr3.
<p>This family of proteins are found both in prokaryotes and eukaryotes. They are related to the human bile acid:sodium symporters (TC 2.A.28), which are transmembrane proteins functioning in the liver in the uptake of bile acids from portal blood plasma, a process mediated by the co-transport of Na<sup>+</sup> [[cite:PUB00004723]].</p> <p>This entry also includes members of the ACR3 family of arsenite (As(III)) permeases, which confer resistance to arsenic by extrusion from cells [[cite:PUB00070752]]. They exist in prokaryotes and eukaryotes (lower plants and fungi) [[cite:PUB00070755], [cite:PUB00070756]]. The ACR3 permeases have ten-transmembrane span topology [[cite:PUB00070754]]. Corynebacterium glutamicum has three Acr3 proteins, CgAcr3-1, CgAcr3-2, and CgAcr3-3. CgAcr3-1 is thought to be an antiporter that catalyses arsenite-proton exchange [[cite:PUB00070753]].</p> <p>The Shewanella oneidensis Acr3 is not able to transport As(III) and confers resistance only to arsenate (As(V)) [[cite:PUB00070758]], whereas the Acr3 orthologue from Synechocystis mediates tolerance to As(III), As(V) and antimonite (Sb(III)) [[cite:PUB00070759]].</p> <p>In budding yeast, overexpression of the Acr3 gene confers an arsenite- but not an arsenate-resistance phenotype [[cite:PUB00005662]]. Saccharomyces cerevisiae Acr3 is a plasma membrane metalloid/H+ antiporter that transports arsenite and antimonite [[cite:PUB00072662]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable sodium/metabolite cotransporter BASS1, chloroplastic-like [Cicer arietinum] gi|502089667|ref|XP_004488981.1| | 7 | ||
| – | PREDICTED: probable sodium/metabolite cotransporter BASS1, chloroplastic-like [Cicer arietinum] gi|502089667|ref|XP_004488981.1| | 8 | ||
| – | PREDICTED: probable sodium/metabolite cotransporter BASS3, chloroplastic-like [Cicer arietinum] gi|502103317|ref|XP_004492253.1| | 8 | ||
| – | PREDICTED: probable sodium/metabolite cotransporter BASS3, chloroplastic-like [Cicer arietinum] gi|502103317|ref|XP_004492253.1| | 8 | ||
| – | Ileal sodium/bile acid cotransporter [Medicago truncatula] gi|357481845|ref|XP_003611208.1| | 8 | ||
| – | PREDICTED: probable sodium/metabolite cotransporter BASS5, chloroplastic-like [Cicer arietinum] gi|502160106|ref|XP_004511635.1| | 8 | ||
| – | Ileal sodium/bile acid cotransporter [Medicago truncatula] gi|357481845|ref|XP_003611208.1| | 8 | ||
| – | Ileal sodium/bile acid cotransporter [Medicago truncatula] gi|357481845|ref|XP_003611208.1| | 8 | ||
| – | Bile acid Na+ symporter family protein [Medicago truncatula] gi|357477833|ref|XP_003609202.1| | 8 | ||
| – | Sodium Bile acid symporter family; TAIR: AT3G25410.1 Sodium Bile acid symporter family; Swiss-Prot: sp|Q8RXE8|BASS3_ARATH Probable sodium/metabolite cotransporter BASS3, chloroplastic; TrEMBL-Plants: tr|A0A151REF7|A0A151REF7_CAJCA Putative sodium-dependent transporter yocS; Found in the gene: LotjaGi1g1v0595200 | 12 | ||
| – | Sodium bile acid symporter family protein; TAIR: AT1G78560.1 Sodium Bile acid symporter family; Swiss-Prot: sp|Q93YR2|BASS1_ARATH Probable sodium/metabolite cotransporter BASS1, chloroplastic; TrEMBL-Plants: tr|A0A1J7HU73|A0A1J7HU73_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0304500 | 11 | ||
| – | Bile acid:sodium symporter; TAIR: AT2G26900.1 Sodium Bile acid symporter family; Swiss-Prot: sp|Q1EBV7|BASS2_ARATH Sodium/pyruvate cotransporter BASS2, chloroplastic; TrEMBL-Plants: tr|G7JU57|G7JU57_MEDTR Bile acid:sodium symporter; Found in the gene: LotjaGi4g1v0265100 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 8.33 |