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IPR003675 is a CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain.
<p>This entry represents a domain found in CAAX prenyl protease 2 from Saccharomyces cerevisiae (RCE1), its human homologue, Lysostaphin resistance protein A from Staphylococcus aureus (LyrA), putative intramembrane proteases (IMPs), and similar sequences found in bacteria, eukaryotes and archaea. This domain shows an all-α configuration [[cite:PUB00090027], [cite:PUB00158975]].</p> <p>Rce1 from S. cerevisiae [[cite:PUB00055945]] is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases [[cite:PUB00090026]]. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis [[cite:PUB00095436]]. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP family, the glutamate IMPs [[cite:PUB00090027]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Cysteine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. | ||
| Cellular component | Membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | ||
| Biological process | CAAX-box protein processing | The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | CAAX amino terminal protease family protein [Arabidopsis lyrata subsp]. lyrata] gi|297836838|ref|XP_002886301.1| | 8 | ||
| – | CAAX amino terminal protease family protein isoform 1 [Theobroma cacao] gi|508710044|gb|EOY01941.1| | 8 | ||
| – | CAAX amino terminal protease family protein isoform 3 [Theobroma cacao] gi|508777629|gb|EOY24885.1| | 12 | ||
| – | Uncharacterized protein TCM_015725 [Theobroma cacao] gi|508776757|gb|EOY24013.1| | 9 | ||
| – | Uncharacterized protein TCM_015725 [Theobroma cacao] gi|508776757|gb|EOY24013.1| | 9 | ||
| – | Os09g0413200 [Oryza sativa Japonica Group] gi|115479137|ref|NP_001063162.1| | 8 | ||
| – | CAAX amino terminal protease family [Cucumis melo subsp]. melo] gi|307135918|gb|ADN33781.1| | 8 | ||
| – | CAAX protease self-immunity protein; TAIR: AT4G17840.1 CAAX protease self-immunity protein; Swiss-Prot: sp|Q30R95|DDL_SULDN D-alanine--D-alanine ligase; TrEMBL-Plants: tr|I3T6T9|I3T6T9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0414300 | 9 | ||
| – | CAAX amino terminal protease family protein; TAIR: AT1G14270.1 CAAX amino terminal protease family protein; Swiss-Prot: sp|O05525|YDIL_BACSU Putative membrane peptidase YdiL; TrEMBL-Plants: tr|I1KXT8|I1KXT8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0090000 | 8 | ||
| – | CAAX amino terminal protease family protein; TAIR: AT3G26085.1 CAAX amino terminal protease family protein; Swiss-Prot: sp|P37513|YYAK_BACSU Uncharacterized protein YyaK; TrEMBL-Plants: tr|I1KSU6|I1KSU6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0391100_LC | 8 | ||
| – | CAAX amino terminal protease family protein; TAIR: AT5G60750.1 CAAX amino terminal protease family protein; Swiss-Prot: sp|O05525|YDIL_BACSU Putative membrane peptidase YdiL; TrEMBL-Plants: tr|I1KPG4|I1KPG4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0431300 | 8 | ||
| – | CAAX prenyl protease 2; TAIR: AT2G36305.1 farnesylated protein-converting enzyme 2; Swiss-Prot: sp|Q8GW19|FACE2_ARATH CAAX prenyl protease 2; TrEMBL-Plants: tr|A0A151RJ88|A0A151RJ88_CAJCA CAAX prenyl protease 2; Found in the gene: LotjaGi5g1v0094400 | 12 | ||
| – | CAAX amino terminal protease family protein; TAIR: AT5G60750.1 CAAX amino terminal protease family protein; Swiss-Prot: sp|O05525|YDIL_BACSU Putative membrane peptidase YdiL; TrEMBL-Plants: tr|A0A151U670|A0A151U670_CAJCA Uncharacterized protein; Found in the gene: LotjaGi5g1v0294900 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 7.69 |