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IPR003780

Source: InterPro

Description

IPR003780 is a COX15/CtaA family.

<p>This is a family of integral membrane proteins. CtaA (also known as heme A synthase) is required for cytochrome aa3 oxidase assembly in Bacillus subtilis [[cite:PUB00008248]]. COX15 is required for cytochrome c oxidase assembly [[cite:PUB00070779]], and is involved in the synthesis of heme A [[cite:PUB00070778], [cite:PUB00097267], [cite:PUB00097268]]. COX15 forms highly stable complexes through hydrophobic interactions, and this multimerization is evolutionarily conserved, independent of heme levels and heme a synthase catalytic activity. There are four conserved histidine residues critical for eukaryotic heme a synthase activity [[cite:PUB00097268]]. Mutations of COX15 are associated with fatal infantile hypertrophic cardiomyopathy and the neurological disorder Leigh syndrome, due to impaired stability (S344P) or catalytic function (R217W).</p> <p>In some cases, heme A synthase is found fused to protoheme IX farnesyltransferase, an enzyme that converts protoheme IX to heme O.</p> <p>In addition, heme A synthase can be found fused with mitochondrial ferredoxin as in etp1 [[cite:PUB00153672]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006784
Biological process Heme a biosynthetic process The chemical reactions and pathways resulting in the formation of heme a, a derivative of heme found in cytochrome aa3.
Subterm of
GO:0016021
Cellular component Integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Subterm of
GO:0016627
Molecular function Oxidoreductase activity, acting on the CH-CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 9

Transcript Name Description Predicted domains Domain count
Lj0g3v0229999.1
– PREDICTED: cytochrome c oxidase assembly protein COX15-like [Glycine max] gi|356501669|ref|XP_003519646.1|
Domains
8
Lj0g3v0230009.1
–
Domains
8
Lj2g3v3335060.1
– PREDICTED: cytochrome c oxidase assembly protein COX15-like [Cicer arietinum] gi|502099712|ref|XP_004491543.1|
Domains
8
Lj5g3v0404930.1
– Cytochrome c oxidase assembly protein COX15-like protein [Medicago truncatula] gi|357495241|ref|XP_003617909.1|
Domains
10
LotjaGi1g1v0011600.1
– Heme A synthase; TAIR: AT5G56090.1 cytochrome c oxidase 15; Swiss-Prot: sp|Q9FKT8|COX15_ARATH Cytochrome c oxidase assembly protein COX15; TrEMBL-Plants: tr|A0A151U2K9|A0A151U2K9_CAJCA Cytochrome c oxidase assembly protein COX15 isogeny; Found in the gene: LotjaGi1g1v0011600
Domains
10
LotjaGi1g1v0011600.2
– Heme A synthase; TAIR: AT5G56090.1 cytochrome c oxidase 15; Swiss-Prot: sp|Q9FKT8|COX15_ARATH Cytochrome c oxidase assembly protein COX15; TrEMBL-Plants: tr|A0A151U2K9|A0A151U2K9_CAJCA Cytochrome c oxidase assembly protein COX15 isogeny; Found in the gene: LotjaGi1g1v0011600
Domains
10
LotjaGi5g1v0043500.1
– Heme A synthase; TAIR: AT5G56090.1 cytochrome c oxidase 15; Swiss-Prot: sp|Q9FKT8|COX15_ARATH Cytochrome c oxidase assembly protein COX15; TrEMBL-Plants: tr|A0A151U2K9|A0A151U2K9_CAJCA Cytochrome c oxidase assembly protein COX15 isogeny; Found in the gene: LotjaGi5g1v0043500
Domains
10
LotjaGi5g1v0043500.2
– Heme A synthase; TAIR: AT5G56090.1 cytochrome c oxidase 15; Swiss-Prot: sp|Q9FKT8|COX15_ARATH Cytochrome c oxidase assembly protein COX15; TrEMBL-Plants: tr|A0A151U2K9|A0A151U2K9_CAJCA Cytochrome c oxidase assembly protein COX15 isogeny; Found in the gene: LotjaGi5g1v0043500
Domains
10
LotjaGi5g1v0043500.3
– Heme A synthase; TAIR: AT5G56090.1 cytochrome c oxidase 15; Swiss-Prot: sp|Q9FKT8|COX15_ARATH Cytochrome c oxidase assembly protein COX15; TrEMBL-Plants: tr|A0A151U2K9|A0A151U2K9_CAJCA Cytochrome c oxidase assembly protein COX15 isogeny; Found in the gene: LotjaGi5g1v0043500
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 11.11