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IPR003780

Description

IPR003780 is a COX15/CtaA family.

<p>This is a family of integral membrane proteins. CtaA (also known as heme A synthase) is required for cytochrome aa3 oxidase assembly in Bacillus subtilis [[cite:PUB00008248]]. COX15 is required for cytochrome c oxidase assembly [[cite:PUB00070779]], and is involved in the synthesis of heme A [[cite:PUB00070778], [cite:PUB00097267], [cite:PUB00097268]]. COX15 forms highly stable complexes through hydrophobic interactions, and this multimerization is evolutionarily conserved, independent of heme levels and heme a synthase catalytic activity. There are four conserved histidine residues critical for eukaryotic heme a synthase activity [[cite:PUB00097268]]. Mutations of COX15 are associated with fatal infantile hypertrophic cardiomyopathy and the neurological disorder Leigh syndrome, due to impaired stability (S344P) or catalytic function (R217W).</p> <p>In some cases, heme A synthase is found fused to protoheme IX farnesyltransferase, an enzyme that converts protoheme IX to heme O.</p> <p>In addition, heme A synthase can be found fused with mitochondrial ferredoxin as in etp1 [[cite:PUB00153672]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Biological process Heme a biosynthetic process The chemical reactions and pathways resulting in the formation of heme a, a derivative of heme found in cytochrome aa3.
Cellular component Integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Molecular function Oxidoreductase activity, acting on the CH-CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

Associated Lotus transcripts 9

Transcript Name Description Predicted domains Domain count
PREDICTED: cytochrome c oxidase assembly protein COX15-like [Glycine max] gi|356501669|ref|XP_003519646.1| 8
8
PREDICTED: cytochrome c oxidase assembly protein COX15-like [Cicer arietinum] gi|502099712|ref|XP_004491543.1| 8
Cytochrome c oxidase assembly protein COX15-like protein [Medicago truncatula] gi|357495241|ref|XP_003617909.1| 10
Heme A synthase; TAIR: AT5G56090.1 cytochrome c oxidase 15; Swiss-Prot: sp|Q9FKT8|COX15_ARATH Cytochrome c oxidase assembly protein COX15; TrEMBL-Plants: tr|A0A151U2K9|A0A151U2K9_CAJCA Cytochrome c oxidase assembly protein COX15 isogeny; Found in the gene: LotjaGi1g1v0011600 10
Heme A synthase; TAIR: AT5G56090.1 cytochrome c oxidase 15; Swiss-Prot: sp|Q9FKT8|COX15_ARATH Cytochrome c oxidase assembly protein COX15; TrEMBL-Plants: tr|A0A151U2K9|A0A151U2K9_CAJCA Cytochrome c oxidase assembly protein COX15 isogeny; Found in the gene: LotjaGi1g1v0011600 10
Heme A synthase; TAIR: AT5G56090.1 cytochrome c oxidase 15; Swiss-Prot: sp|Q9FKT8|COX15_ARATH Cytochrome c oxidase assembly protein COX15; TrEMBL-Plants: tr|A0A151U2K9|A0A151U2K9_CAJCA Cytochrome c oxidase assembly protein COX15 isogeny; Found in the gene: LotjaGi5g1v0043500 10
Heme A synthase; TAIR: AT5G56090.1 cytochrome c oxidase 15; Swiss-Prot: sp|Q9FKT8|COX15_ARATH Cytochrome c oxidase assembly protein COX15; TrEMBL-Plants: tr|A0A151U2K9|A0A151U2K9_CAJCA Cytochrome c oxidase assembly protein COX15 isogeny; Found in the gene: LotjaGi5g1v0043500 10
Heme A synthase; TAIR: AT5G56090.1 cytochrome c oxidase 15; Swiss-Prot: sp|Q9FKT8|COX15_ARATH Cytochrome c oxidase assembly protein COX15; TrEMBL-Plants: tr|A0A151U2K9|A0A151U2K9_CAJCA Cytochrome c oxidase assembly protein COX15 isogeny; Found in the gene: LotjaGi5g1v0043500 10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 11.11