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IPR004298 is a Nicotianamine synthase.
<p>Nicotianamine synthase [ec:2.5.1.43] catalyzes the trimerization of S-adenosylmethionine to yield one molecule of nicotianamine. Nicotianamine has an important role in plant iron uptake mechanisms. Plants adopt two strategies (termed I and II) of iron acquisition. Strategy I is adopted by all higher plants except graminaceous plants, which adopt strategy II [[cite:PUB00007476], [cite:PUB00007477]]. In strategy I plants, the role of nicotianamine is not fully determined: possible roles include the formation of more stable complexes with ferrous than with ferric ion, which might serve as a sensor of the physiological status of iron within a plant, or which might be involved in the transport of iron [[cite:PUB00007476]]. In strategy II (graminaceous) plants, nicotianamine is the key intermediate (and nicotianamine synthase the key enzyme) in the synthesis of the mugineic family (the only known family in plants) of phytosiderophores. Phytosiderophores are iron chelators whose secretion by the roots is greatly increased in instances of iron deficiency [[cite:PUB00007477]].</p> <p>The 3D structures of five example NAS from Methanothermobacter thermautotrophicus reveal the monomer to consist of a five-helical bundle N-terminal domain on top of a classic Rossmann fold C-terminal domain. The N-terminal domain is unique to the NAS family, whereas the C-terminal domain is homologous to the class I family of SAM-dependent methyltransferases. An active site is created at the interface of the two domains, at the rim of a large cavity that corresponds to the nucleotide binding site such as is found in other proteins adopting a Rossmann fold [[cite:PUB00054692]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Nicotianamine synthase activity | Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H(+) + nicotianamine. | ||
| Biological process | Nicotianamine biosynthetic process | The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Nicotianamine synthase [Lotus japonicus] gi|223588270|dbj|BAH22562.1| | 9 | ||
| – | PREDICTED: nicotianamine synthase-like [Cicer arietinum] gi|502088019|ref|XP_004488704.1| | 9 | ||
| – | Nicotianamine synthase [Lotus japonicus] gi|223588272|dbj|BAH22563.1| | 7 | ||
| – | Nicotianamine synthase; TAIR: AT5G04950.1 nicotianamine synthase 1; Swiss-Prot: sp|Q9XGI7|NAS_SOLLC Nicotianamine synthase; TrEMBL-Plants: tr|B9A9Z1|B9A9Z1_LOTJA Nicotianamine synthase; Found in the gene: LotjaGi1g1v0748300 | 9 | ||
| – | Nicotianamine synthase; TAIR: AT5G56080.1 nicotianamine synthase 2; Swiss-Prot: sp|Q9XGI7|NAS_SOLLC Nicotianamine synthase; TrEMBL-Plants: tr|A0A072V9C6|A0A072V9C6_MEDTR Nicotianamine synthase; Found in the gene: LotjaGi3g1v0145000 | 9 | ||
| – | Nicotianamine synthase; TAIR: AT5G04950.1 nicotianamine synthase 1; Swiss-Prot: sp|Q9XGI7|NAS_SOLLC Nicotianamine synthase; TrEMBL-Plants: tr|I3SNB0|I3SNB0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0258100 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR32266:SF17 | PANTHER | 1 | 16.67 |