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IPR004313

Source: InterPro

Description

IPR004313 is a Acireductone dioxygenase ARD family.

<p>The two acireductone dioxygenase enzymes (ARD and ARD', previously known as E-2 and E-2') from Klebsiella pneumoniae share the same amino acid sequence [swissprot:Q9ZFE7], but bind different metal ions: ARD binds Ni2+, ARD' binds Fe2+ [[cite:PUB00007489]]. ARD and ARD' can be experimentally interconverted by removal of the bound metal ion and reconstitution with the appropriate metal ion. The two enzymes share the same substrate, 1,2-dihydroxy-3-keto-5-(methylthio)pentene, but yield different products. ARD' yields the alpha-keto precursor of methionine (and formate), thus forming part of the ubiquitous methionine salvage pathway that converts 5'-methylthioadenosine (MTA) to methionine. This pathway is responsible for the tight control of the concentration of MTA, which is a powerful inhibitor of polyamine biosynthesis and transmethylation reactions [[cite:PUB00007490]]. ARD yields methylthiopropanoate, carbon monoxide and formate, and thus prevents the conversion of MTA to methionine. The role of the ARD catalysed reaction is unclear: methylthiopropanoate is cytotoxic, and carbon monoxide can activate guanylyl cyclase, leading to increased intracellular cGMP levels [[cite:PUB00007490], [cite:PUB00007489]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0010309
Molecular function Acireductone dioxygenase [iron(II)-requiring] activity Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+).
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 10

Transcript Name Description Predicted domains Domain count
Lj1g3v0112720.1
– PREDICTED: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like [Cicer arietinum] gi|502119608|ref|XP_004496677.1|
Domains
8
Lj1g3v0112750.1
– PREDICTED: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 3-like isoform X2 [Cicer arietinum] gi|502119599|ref|XP_004496674.1|
Domains
7
Lj1g3v0112780.1
– PREDICTED: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 3-like isoform X2 [Cicer arietinum] gi|502119599|ref|XP_004496674.1|
Domains
7
Lj3g3v0754950.1
– PREDICTED: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like [Cicer arietinum] gi|502119608|ref|XP_004496677.1|
Domains
9
Lj5g3v2045460.1
– PREDICTED: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like [Cicer arietinum] gi|502119608|ref|XP_004496677.1|
Domains
8
LotjaGi3g1v0091100_LC.1
– 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; TAIR: AT5G43850.1 RmlC-like cupins superfamily protein; Swiss-Prot: sp|D7T737|MTND1_VITVI 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1; TrEMBL-Plants: tr|I3SR18|I3SR18_LOTJA 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Found in the gene: LotjaGi3g1v0091100_LC
Domains
9
LotjaGi3g1v0091100_LC.2
– 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; TAIR: AT5G43850.1 RmlC-like cupins superfamily protein; Swiss-Prot: sp|D7T737|MTND1_VITVI 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1; TrEMBL-Plants: tr|I3SR18|I3SR18_LOTJA 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Found in the gene: LotjaGi3g1v0091100_LC
Domains
9
LotjaGi5g1v0310400.1
– 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; TAIR: AT4G14710.1 RmlC-like cupins superfamily protein; Swiss-Prot: sp|F6HDT7|MTND2_VITVI 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2; TrEMBL-Plants: tr|I3SYE6|I3SYE6_LOTJA 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Found in the gene: LotjaGi5g1v0310400
Domains
10
LotjaGi5g1v0310400.2
– 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; TAIR: AT4G14710.1 RmlC-like cupins superfamily protein; Swiss-Prot: sp|F6HDT7|MTND2_VITVI 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2; TrEMBL-Plants: tr|I3SYE6|I3SYE6_LOTJA 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Found in the gene: LotjaGi5g1v0310400
Domains
10
LotjaGi5g1v0310600.1
– 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; TAIR: AT5G43850.1 RmlC-like cupins superfamily protein; Swiss-Prot: sp|D7T737|MTND1_VITVI 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1; TrEMBL-Plants: tr|I3SR18|I3SR18_LOTJA 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Found in the gene: LotjaGi5g1v0310600
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF51182 SUPERFAMILY 1 10.00