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IPR027496

Description

IPR027496 is a Acireductone dioxygenase, eukaryotes.

<p>Acireductone dioxygenase (ARD/MTND, also known as 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [ec:1.13.11.54]) is an eukaryotic enzyme that catalyses the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). It shows significant homology to the bacterial acireductone dioxygenase (ARD), which is an enzyme in the methionine salvage pathway (MTA cycle) [[cite:PUB00064756], [cite:PUB00064753], [cite:PUB00100761]]]. MTCBP-1 is necessary for hepatitis C virus replication in an otherwise non-permissive cell line [[cite:PUB00064746]]. MTCBP-1 interacts and inhibits the activity of membrane-type 1 matrix metalloproteinase (MT1-MMP/MMP-14) in promoting tumor cell migration and invasion [[cite:PUB00064753]].</p> <p>MTCBP-1 contains the cupin sequence motif and belongs to the Cupin superfamily composed of proteins with diverse functions [[cite:PUB00064753]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
Biological process L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; TAIR: AT4G14710.1 RmlC-like cupins superfamily protein; Swiss-Prot: sp|F6HDT7|MTND2_VITVI 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2; TrEMBL-Plants: tr|I3SYE6|I3SYE6_LOTJA 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Found in the gene: LotjaGi5g1v0310400 10
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; TAIR: AT4G14710.1 RmlC-like cupins superfamily protein; Swiss-Prot: sp|F6HDT7|MTND2_VITVI 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2; TrEMBL-Plants: tr|I3SYE6|I3SYE6_LOTJA 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Found in the gene: LotjaGi5g1v0310400 10
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; TAIR: AT5G43850.1 RmlC-like cupins superfamily protein; Swiss-Prot: sp|D7T737|MTND1_VITVI 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1; TrEMBL-Plants: tr|I3SR18|I3SR18_LOTJA 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Found in the gene: LotjaGi5g1v0310600 10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF51182 SUPERFAMILY 1 33.33