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IPR004551

Source: InterPro

Description

IPR004551 is a Diphthine synthase.

<p>Diphthine synthase ([ec:2.1.1.98]), also known as diphthamide biosynthesis S-adenosylmethionine-dependent methyltransferase, participates in the modification of a specific histidine residue in elongation factor 2 (EF-2) of eukaryotes and archaea to diphthamide. It is required for the methylation step in dipthamide biosynthesis.</p> <p>This entry also includes diphthine methyl ester synthase ([ec:2.1.1.314]) from Saccharomyces cerevisiae (a product of the DPH5 gene), which is an S-adenosyl-L-methionine-dependent methyltransferase that catalyzes methylations of a modified histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester: the second step of diphthamide biosynthesis [[cite:PUB00084383]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004164
Molecular function Diphthine synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine.
Subterm of
GO:0017183
Biological process Peptidyl-diphthamide biosynthetic process from peptidyl-histidine The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.
Subterm of

Associated Lotus transcripts 5

Transcript Name Description Predicted domains Domain count
Lj5g3v1807020.1
– PREDICTED: probable diphthine synthase-like [Glycine max] gi|356521535|ref|XP_003529410.1|
Domains
14
Lj5g3v1807020.2
– PREDICTED: probable diphthine synthase-like [Glycine max] gi|356521535|ref|XP_003529410.1|
Domains
13
LotjaGi1g1v0428200.1
– Diphthine synthase-like protein; TAIR: AT4G31790.1 Tetrapyrrole (Corrin/Porphyrin) Methylase; Swiss-Prot: sp|O81769|DPH5_ARATH Probable diphthine methyl ester synthase; TrEMBL-Plants: tr|A0A0R4J642|A0A0R4J642_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0428200
Domains
15
LotjaGi1g1v0428200.2
– Diphthine synthase-like protein; TAIR: AT4G31790.1 Tetrapyrrole (Corrin/Porphyrin) Methylase; Swiss-Prot: sp|O81769|DPH5_ARATH Probable diphthine methyl ester synthase; TrEMBL-Plants: tr|A0A0R4J642|A0A0R4J642_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0428200
Domains
15
LotjaGi5g1v0272000.1
– Diphthine synthase-like protein; TAIR: AT4G31790.1 Tetrapyrrole (Corrin/Porphyrin) Methylase; Swiss-Prot: sp|O81769|DPH5_ARATH Probable diphthine methyl ester synthase; TrEMBL-Plants: tr|A0A0R0JDS4|A0A0R0JDS4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0272000
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd11647 CDD 1 20.00