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IPR004595 is a TFIIH C1-like domain.
<p>The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domains. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C [[cite:PUB00016526]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | ||
| Molecular function | Zinc ion binding | Interacting selectively and non-covalently with zinc (Zn) ions. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | General transcription factor IIH subunit [Medicago truncatula] gi|357509341|ref|XP_003624959.1| | 20 | ||
| – | GTF2H2; TAIR: AT1G05055.1 general transcription factor II H2; Swiss-Prot: sp|Q9ZVN9|TF2H2_ARATH General transcription factor IIH subunit 2; TrEMBL-Plants: tr|A0A1J7IMI8|A0A1J7IMI8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0661700 | 22 | ||
| – | GTF2H2; TAIR: AT1G05055.1 general transcription factor II H2; Swiss-Prot: sp|Q9ZVN9|TF2H2_ARATH General transcription factor IIH subunit 2; TrEMBL-Plants: tr|G7L5Y2|G7L5Y2_MEDTR General transcription factor IIH subunit 2; Found in the gene: LotjaGi1g1v0661700 | 22 | ||
| – | GTF2H2; TAIR: AT1G05055.1 general transcription factor II H2; Swiss-Prot: sp|Q9ZVN9|TF2H2_ARATH General transcription factor IIH subunit 2; TrEMBL-Plants: tr|A0A1J7IMI8|A0A1J7IMI8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0661700 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |