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IPR004861 is a Atypical dual-specificity phosphatase Siw14-like.
<p>This group of atypical dual-specificity phosphatases are predominantly from fungi, plants and bacteria. This entry includes budding yeast Siw14 (also known as Oca3) and related proteins. Siw14 is a inositol pyrophosphate phosphatase that modulates inositol pyrophosphate metabolism by dephosphorylating the IP7 isoform 5PP-IP5to IP6 [[cite:PUB00088170]]. This entry also includes budding yeast Oca1/2/4/6 and Arabidopsis DSP1/2/3/4/5. All DSPs tested (AtPFA-DSP1, -2, -3, and -5) displayed phosphatase activity toward PI(3,5)P2, with AtPFA-DSP2 showing a higher activity [[cite:PUB00088172]]. Oca1/2/4/6 are putative phosphatases associated with the caffeine-sensitivity stress pathway in S. cerevisiae [[cite:PUB00088172]]. It also includes dual specificity protein phosphatase TpbA that regulates diverse phenotypes in P.aeruginosa via regulation of the concentration of cellular c-di-GMP [[cite:PUB00078743]]. This phosphatase acts by dephosphorylating the membrane-anchored diguanylate cyclase TpbB at tyrosine and serine/threonine sites, leading to inactivation of TpbB and reduced c-di-GMP production [[cite:PUB00078743], [cite:PUB00151104]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Tyrosine specific protein phosphatase family protein [Medicago truncatula] gi|357493185|ref|XP_003616881.1| | 14 | ||
| – | Tyrosine specific protein phosphatase family protein [Medicago truncatula] gi|357493185|ref|XP_003616881.1| | 12 | ||
| – | PREDICTED: probable tyrosine-protein phosphatase At1g05000-like [Cicer arietinum] gi|502105563|ref|XP_004492836.1| | 11 | ||
| – | PREDICTED: probable tyrosine-protein phosphatase At1g05000-like [Glycine max] gi|356522035|ref|XP_003529655.1| | 11 | ||
| – | Tyrosine-protein phosphatase; TAIR: AT1G05000.1 Phosphotyrosine protein phosphatases superfamily protein; Swiss-Prot: sp|Q9ZVN4|Y1500_ARATH Probable tyrosine-protein phosphatase At1g05000; TrEMBL-Plants: tr|A0A0L9UVM0|A0A0L9UVM0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0067300 | 13 | ||
| – | Tyrosine phosphatase family protein; TAIR: AT3G02800.1 Tyrosine phosphatase family protein; Swiss-Prot: sp|Q9ZVN4|Y1500_ARATH Probable tyrosine-protein phosphatase At1g05000; TrEMBL-Plants: tr|I3T9B5|I3T9B5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0484900 | 12 | ||
| – | Tyrosine-protein phosphatase; TAIR: AT4G03960.1 Phosphotyrosine protein phosphatases superfamily protein; Swiss-Prot: sp|Q9ZVN4|Y1500_ARATH Probable tyrosine-protein phosphatase At1g05000; TrEMBL-Plants: tr|I1KNI1|I1KNI1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0009900 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd14528 | CDD | 1 | 14.29 |