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IPR005455 is a Profilin, eukaryotic type.
<p>This entry represents the Profilin family, which are small eukaryotic proteins that have different functions. In plants, they are major allergens present in pollens [[cite:PUB00063828]].</p> <p>The majority of the Profilin family members binds to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerisation of actin into filaments (F-actin). They can also in certain circumstance promote actin polymerisation [[cite:PUB00071235]]. However, some Profilin family members, such as Profilin4 from mammals, does not binds to actin and may have functions distinct from regulating actin dynamics [[cite:PUB00071234]]. It plays a role in the assembly of branched actin filament networks, by activating WASP via binding to WASP's proline rich domain [[cite:PUB00081657]]. Profilin may link the cytoskeleton with major signalling pathways by interacting with components of the phosphatidylinositol cycle and Ras pathway [[cite:PUB00000725], [cite:PUB00018867]].</p> <p>Some Profilins can also bind to polyphosphoinositides such as PIP2 [[cite:PUB00063827]]. Overall sequence similarity among profilin from organisms which belong to different phyla (ranging from fungi to mammals) is low, but the N-terminal region is relatively well conserved. The N-terminal region is thought to be involved in actin binding.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Profilin family protein [Theobroma cacao] gi|508778144|gb|EOY25400.1| | 6 | ||
| – | Profilin [Arachis hypogaea] gi|284810529|gb|ADB96066.1| | 10 | ||
| – | PREDICTED: profilin-like [Glycine max] gi|356513177|ref|XP_003525290.1| | 12 | ||
| – | PREDICTED: profilin-1-like [Cicer arietinum] gi|502138696|ref|XP_004503498.1| | 12 | ||
| – | Profilin; TAIR: AT4G19400.1 Profilin family protein; Swiss-Prot: sp|Q6PI53|MED24_XENLA Mediator of RNA polymerase II transcription subunit 24; TrEMBL-Plants: tr|I3SB44|I3SB44_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0783800 | 6 | ||
| – | Profilin; TAIR: AT4G19400.1 Profilin family protein; Swiss-Prot: sp|C4V6H6|HSF_NOSCE Probable heat shock factor protein homolog; TrEMBL-Plants: tr|I1NCB9|I1NCB9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0783800 | 6 | ||
| – | Profilin; TAIR: AT2G19760.1 profilin 1; Swiss-Prot: sp|O82572|PROF1_RICCO Profilin-1; TrEMBL-Plants: tr|I3SDB5|I3SDB5_LOTJA Profilin; Found in the gene: LotjaGi2g1v0227200 | 13 | ||
| – | Profilin; TAIR: AT4G29340.1 profilin 4; Swiss-Prot: sp|A4KA45|PROF4_CORAV Profilin-4; TrEMBL-Plants: tr|I3T4D9|I3T4D9_LOTJA Profilin; Found in the gene: LotjaGi2g1v0227300 | 13 | ||
| – | Profilin; TAIR: AT2G19770.1 profilin 5; Swiss-Prot: sp|A4KA45|PROF4_CORAV Profilin-4; TrEMBL-Plants: tr|I3S141|I3S141_LOTJA Profilin; Found in the gene: LotjaGi4g1v0444000 | 13 | ||
| – | Profilin; TAIR: AT4G29340.1 profilin 4; Swiss-Prot: sp|A4KA45|PROF4_CORAV Profilin-4; TrEMBL-Plants: tr|I3S141|I3S141_LOTJA Profilin; Found in the gene: LotjaGi4g1v0444000 | 13 | ||
| – | Profilin; TAIR: AT2G19760.1 profilin 1; Swiss-Prot: sp|P49231|PROF1_PHAVU Profilin-1; TrEMBL-Plants: tr|I3T443|I3T443_LOTJA Profilin; Found in the gene: LotjaGi4g1v0444200 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00148 | CDD | 1 | 9.09 |