Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR005803 is a Fatty acid desaturase type 2, conserved site.
<p>This conserved region is found at the C-terminal part of family 2 enzymes.</p> <p>Fatty acid desaturases are enzymes that catalyse the insertion of a double bond at the delta position of fatty acids. There seem to be two distinct families of fatty acid desaturases which do not seem to be evolutionary related.</p> <p>Family 1 is composed of:</p> <ul><li>Stearoyl-CoA desaturase (SCD) ([ec:1.14.19.1]) [[cite:PUB00002505]].</li></ul> <p>Family 2 is composed of:</p> <ul> <li>Bacterial fatty acid desaturases.</li> <li>Plant stearoyl-acyl-carrier-protein desaturase ([ec:1.14.19.1]) [[cite:PUB00004734]], this enzyme catalyzes the introduction of a double bond at the delta(9) position of steraoyl-ACP to produce oleoyl-ACP. This enzyme is responsible for the conversion of saturated fatty acids to unsaturated fatty acids in the synthesis of vegetable oils.</li> <li>Cyanobacterial DesA [[cite:PUB00004074]], an enzyme that can introduce a second cis double bond at the delta(12) position of fatty acid bound to membranes glycerolipids. DesA is involved in chilling tolerance; the phase transition temperature of lipids of cellular membranes being dependent on the degree of unsaturation of fatty acids of the membrane lipids.</li> </ul> <p>Members of this entry are endoplasmic reticulum (ER) integral membrane proteins that share the same mushroom-like shape fold consisting of four transmembrane helices (TM1-TM4) which anchor them to the membrane, capped by a cytosolic domain containing a unique 9-10 histidine-coordinating di metal (di-iron) catalytic centre [[cite:PUB00098457], [cite:PUB00098458]]. The structure of mouse stearoyl-CoA desaturase (SDC) revealed that TM2 and TM4 are longer than TM1 and TM3 and protrude into the cytosolic domain, providing three of the nine histidine residues that coordinate the two metal ions, while the other histidine residues are provided by the soluble domain in this enzyme [[cite:PUB00098457]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. | ||
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Acyl-[acyl]-carrier-protein] gi|67633223|gb|AAY78547.1| | 16 | ||
| – | Acyl-[acyl]-carrier-protein] gi|67633223|gb|AAY78547.1| | 16 | ||
| – | Acyl-[acyl]-carrier-protein] desaturase; TAIR: AT2G43710.1 Plant stearoyl-acyl-carrier-protein desaturase family protein; Swiss-Prot: sp|Q42807|STAD_SOYBN Stearoyl-[acyl]-carrier-protein] 9-desaturase, chloroplastic; TrEMBL-Plants: tr|Q4PZD4|Q4PZD4_LOTJA Acyl-[acyl]-carrier-protein] desaturase; Found in the gene: LotjaGi4g1v0068200 | 17 | ||
| – | Acyl-[acyl]-carrier-protein] desaturase; TAIR: AT2G43710.1 Plant stearoyl-acyl-carrier-protein desaturase family protein; Swiss-Prot: sp|Q42807|STAD_SOYBN Stearoyl-[acyl]-carrier-protein] 9-desaturase, chloroplastic; TrEMBL-Plants: tr|Q4PZD4|Q4PZD4_LOTJA Acyl-[acyl]-carrier-protein] desaturase; Found in the gene: LotjaGi4g1v0068200 | 12 | ||
| – | Acyl-[acyl]-carrier-protein] desaturase; TAIR: AT2G43710.2 Plant stearoyl-acyl-carrier-protein desaturase family protein; Swiss-Prot: sp|Q42807|STAD_SOYBN Stearoyl-[acyl]-carrier-protein] 9-desaturase, chloroplastic; TrEMBL-Plants: tr|Q4PZD4|Q4PZD4_LOTJA Acyl-[acyl]-carrier-protein] desaturase; Found in the gene: LotjaGi4g1v0068200 | 12 | ||
| – | Acyl-[acyl]-carrier-protein] desaturase; TAIR: AT2G43710.1 Plant stearoyl-acyl-carrier-protein desaturase family protein; Swiss-Prot: sp|Q42807|STAD_SOYBN Stearoyl-[acyl]-carrier-protein] 9-desaturase, chloroplastic; TrEMBL-Plants: tr|Q4PZD4|Q4PZD4_LOTJA Acyl-[acyl]-carrier-protein] desaturase; Found in the gene: LotjaGi4g1v0068200 | 18 | ||
| – | Acyl-[acyl]-carrier-protein] desaturase; TAIR: AT2G43710.1 Plant stearoyl-acyl-carrier-protein desaturase family protein; Swiss-Prot: sp|Q42807|STAD_SOYBN Stearoyl-[acyl]-carrier-protein] 9-desaturase, chloroplastic; TrEMBL-Plants: tr|Q4PZD4|Q4PZD4_LOTJA Acyl-[acyl]-carrier-protein] desaturase; Found in the gene: LotjaGi4g1v0068200 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01050 | CDD | 1 | 14.29 |